| Matches by round |
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
| Match list: | By round By date Latest | Player stats: |
| R | Date | Home | Score | Away | Location | |
| 1 | 03/10/2010 | Sirens | 1 - 3 | Ghaxaq | Centenary Stadium | |
| 2 | 10/10/2010 | Pembroke A. | 2 - 0 | Sirens | Centenary Stadium | |
| 3 | 17/10/2010 | Gozo | 2 - 3 | Sirens | Sannat Ground | |
| 4 | 05/11/2010 | Fgura U. | 2 - 1 | Sirens | Centenary Stadium | |
| 5 | 15/11/2010 | Sirens | 2 - 4 | Kirkop U. | Centenary Stadium | |
| 6 | 26/11/2010 | Marsa | 2 - 2 | Sirens | Centenary Stadium | |
| 7 | 08/12/2010 | Sirens | 2 - 2 | Gharghur | Centenary Stadium | |
| 8 | 17/12/2010 | Luqa SA | 0 - 0 | Sirens | Centenary Stadium | |
| 9 | 07/01/2011 | Kalkara | 2 - 4 | Sirens | Centenary Stadium | |
| 10 | 16/01/2011 | Ghaxaq | 1 - 3 | Sirens | Centenary Stadium | |
| 11 | 11/02/2011 | Sirens | 2 - 3 | Pembroke A. | Centenary Stadium | |
| 12 | 22/02/2011 | Sirens | 3 - 0 | Gozo | Centenary Stadium | |
| 13 | 27/02/2011 | Sirens | 3 - 3 | Fgura U. | Centenary Stadium | |
| 14 | 13/03/2011 | Kirkop U. | 2 - 2 | Sirens | Centenary Stadium | |
| 15 | 21/03/2011 | Sirens | 2 - 1 | Marsa | Centenary Stadium | |
| 16 | 28/03/2011 | Gharghur | 1 - 0 | Sirens | Centenary Stadium | |
| 17 | 04/04/2011 | Sirens | 3 - 5 | Luqa SA | Centenary Stadium | |
| 18 | 19/04/2011 | Sirens | 3 - 1 | Kalkara | Centenary Stadium |