| Date | Home | vs | Away | Result | Scorers |
| 23-Nov | Marsaskala | vs | Luqa SA | 0-6 | Miguel Vella, Nathan Frendo (2), Julian Muscat, Isaac Vella, Thomas Antoine Debono |
| 23-Nov | Tarxien R. | vs | Naxxar L. | 0-5 | Kurt Galea (2), Jake Agius (2), Leon Camilleri |
| 23-Nov | Pembroke A. | vs | Sliema W. | 2-1 | Jacob Carabott (2)(P); Marcus Calleja (S) |
| 24-Nov | Rabat A. | vs | Mellieha | 1-1 | Hatim Balzan (M); Kyle Schembri (R) |
| 30-Nov | Pembroke A. | vs | Tarxien R. | 1-0 | Caine Attard |
| 01-Dec | Rabat A. | vs | Naxxar L. | 4-2 | Tristan Schembri (3), Robbie Fenech (R); Jake Agius (2)(N) |
| 01-Dec | Mellieha | vs | Luqa SA | 0-6 | Nathan Frendo (3), Miguel Abela, Andreas Psaila (2) |
| 01-Dec | Sliema W. | vs | Marsaskala | 3-2 | Elton Cachia (2)(M); Thomas Cilia, Cleaven Cassar, Aaron Alfredo Doda (S) |
| 07-Dec | Marsaskala | vs | Rabat A. | 0-6 | Samuel Luke Berman, Jake Cordina (3), Andre Debattista (2) |
| 08-Dec | Tarxien R. | vs | Mellieha | 3-1 | Daphnes Massa, Danilo Marmara, Miguel Mangion (T); Craig Cilia (M) |
| 08-Dec | Luqa SA | vs | Sliema W. | 0-1 | Marcus Calleja |
| 22-Dec | Naxxar L. | vs | Pembroke A. | 1-0 | Jake Agius |
| 04-Jan | Sliema W. | vs | Rabat A. | 1-1 | Tristan Schembri (R); Thomas Cilia (S) |
| 04-Jan | Luqa SA | vs | Pembroke A. | 2-1 | Nathan Frendo (2)(L); Xylon Marmara (P) |
| 05-Jan | Tarxien R. | vs | Marsaskala | 4-1 | Kyle Camilleri (2), Abdul Karim Kasem, Danilo Marmara (T); own goal (M) |
| 11-Jan | Mellieha | vs | Naxxar L. | 1-2 | own goal (M); Jake Agius, Julian Mercieca (N) |
| 18-Jan | Pembroke A. | vs | Rabat A. | 1-4 | Shylon Vella (3), Jake Cordina (R); Caine Attard (P) |
| 19-Jan | Naxxar L. | vs | Sliema W. | 0-1 | Alexander Spiteri |
| 19-Jan | Marsaskala | vs | Mellieha | 3-1 | Hatim Balzan (Mel); Ethan Lawrence Saliba, Cody Grech, Elton Cachia (Msk) |
| 19-Jan | Luqa SA | vs | Tarxien R. | 5-0 | Nathan Frendo (2), Isaac Vella, Julian Muscat, Thomas Antoine Debono |
| 01-Feb | Mellieha | vs | Pembroke A. | 0-3 | Isaac Grima, Nathan Mizzi, Cedric Muscat |
| 02-Feb | Rabat A. | vs | Luqa SA | 2-0 | Kyle Schembri, Aydan Vic Zammit |
| 02-Feb | Naxxar L. | vs | Marsaskala | 7-1 | Elton Cachia (M); Daniel Joseph Vella, Kurt Galea, Jake Agius (3), Owen Tanti, Gabriel Xuereb (N) |
| 02-Feb | Sliema W. | vs | Tarxien R. | 2-1 | Nathan Vella, Julia Pullicino (S); Abdel Karim Kasem (T) |
| 08-Feb | Mellieha | vs | Sliema W. | 0-4 | Alexander Spiteri (3), Jean Claude Bugeja Aboumehdi |
| 08-Feb | Pembroke A. | vs | Marsaskala | 0-1 | Dante Camilleri |
| 09-Feb | Luqa SA | vs | Naxxar L. | 2-1 | Nathan Frendo, Isaac Vella (L); Kurt Galea (N) |
| 09-Feb | Tarxien R. | vs | Rabat A. | 3-6 | Tristan Schembri (4), Robbie Fenech, Jake Cordina (R); Kyle Camilleri (2), Danilo Marmaa (T) |
| 15-Feb | Melieha | vs | Rabat A. | 0-3 | Shylon Vella (2), Kyle Schembri |
| 16-Feb | Naxxar | vs | Tarxien | 1-0 | Isaac Magri |
| 16-Feb | Luqa SA | vs | Marsaskala | 5-1 | Steve Baldacchino, Andreas Psaila, Nathan Frendo (2), Miguel Abela (L); Elton Cachia (M) |
| 22-Feb | Sliema W. | vs | Pembroke A. | 3-1 | Alexander Spiteri, Nathan Vella, Giorgi Bodokia (S); Cedric Muscat (P) |
| 07-Mar | Naxxar L. | vs | Rabat A. | 3-1 | Kurt Galea (3)(N); Jake Cordina (R) |
| 07-Mar | Marsaskala | vs | Sliema W. | 2-4 | Alexander Spiteri (4)(S); Dante Camilleri (2)(M) |
| 08-Mar | Luqa SA | vs | Mellieha | 4-2 | Nathan Camilleri, Jake Steven Xuereb (M); Julian Muscat, Steve Baldacchino (2), Andreas Psaila (L) |
| 08-Mar | Tarxien R. | vs | Pembroke A. | 1-4 | Xylon Marmara, Caine Attard (2), Isaac Grima (P); Abdul Karim Kasem (T) |
Remaining matches were initially postponed and later cancelled following a decision by the MFA Executive Committee to end all competitions on April 29 due to the COVID-19 pandemic.