| Date | Home | vs | Away | Result | Scorers |
| 12-Oct | Zebbug R. | vs | Raiders GFC | 2-6 | Eva Codermatz, Ylenia Grech (2), Sarah Vella Barberi (2), Suzanne Farrugia Sacco (R); Thea Ida Scicluna, Estelle Borg (Z) |
| 12-Oct | Kirkop U. | vs | Birkirkara | 2-2 | Martina Spiteri (2)(K); Lexine Farrugia (2)(B) |
| 12-Oct | Mtarfa | vs | Senglea A. | 0-4 | Hazel Mizzi (4) |
| 12-Oct | Mgarr U. | vs | Swieqi U. | 2-8 | Iulia MIfsud (5), Aisha Micallef, Kim Fava, Tammy Falzon (S); Ruth Micallef (2)(M) |
| 19-Oct | Mosta | vs | Zebbug R. | 0-10 | Ileana Farrugia (5), Lana Montebello (3), Francesca Bartolo (2) |
| 19-Oct | Swieqi U. | vs | Kirkop U. | 8-1 | Maria Vella (2), Michaela Cachia (2), Kim Fava, Tammy Falzon, Iulia Mifsud (2)(S); Martina Spiteri (K) |
| 19-Oct | Raiders GFC | vs | Mtarfa | 14-0 | Eva Codermatz (2), Sabrin Blihi (2), Suzanne Farrugia Sacco (3), Kate Paula Muscat, Sarah Vella Barberi (3), Michela Micallef (2), Rachel Ann Ciantar |
| 19-Oct | Senglea A. | vs | Mgarr U. | 0-8 | Ruth Micallef (5), Thea Tedesco (2), Kayah Abela Sciberras |
| 26-Oct | Birkirkara | vs | Mosta | 5-1 | Lucia Said (2), Jade Brincat (2), Lexine Farrugia (B); Yasmin Sajeba (M) |
| 26-Oct | Kirkop U. | vs | Senglea A. | 6-0 | Martina Spiteri (3), Hailey Grech, Federica Zahra (2) |
| 26-Oct | Zebbug R. | vs | Mtarfa | 23-0 | Alicia Mifsud (2), Estelle Borg (2), Ileana Farrugia (8), Thea Ida Scicluna, Lana Montebello (2), Francesca Bartolo (4), Danyla Bartolo, Iliana Agius, Angie Borg (2) |
| 26-Oct | Mgarr U. | vs | Raiders GFC | 1-1 | Thea Tedesco (M); Eva Codermatz (R) |
| 02-Nov | Mosta | vs | Swieqi U. | 1-7 | Tammy Falzon (2), Iulia Mifsud (2), Aisha Micallef, Michaela Cachia, own goal (S); Yulya Carella (M) |
| 02-Nov | Raiders GFC | vs | Kirkop U. | 2-1 | Sabrin Bilhi, own goal (R); Federica Zahra (K) |
| 02-Nov | Birkirkara | vs | Zebbug R. | 3-0 | Jade Brincat, Stella Francalanza, Lucia Said |
| 02-Nov | Mtarfa | vs | Mgarr U. | 0-10 | Faith Schembri (2), Joelle Marie Sammut (2), Ruth Micallef, own goals (2), Luisa Maniscalco, Leanne Frendo (2) |
| 09-Nov | Senglea A. | vs | Mosta | 0-3 | Yulya Carella (2), Ivana Schembri |
| 09-Nov | Kirkop U. | vs | Mtarfa | 5-0 | Shanelle Mazzitelli, Martina Spiteri (4) |
| 09-Nov | Swieqi U. | vs | Birkirkara | 5-3 | Michaela Cachia, Tammy Falzon, Kim Fava, Kaysia Micallef, Iulia Mifsud (S); Lexine Farrugia (2), Amelia Falzon (B) |
| 09-Nov | Zebbug R. | vs | Mgarr U. | 2-0 | Francesca Bartolo, Angie Borg |
| 23-Nov | Mosta | vs | Raiders GFC | 1-8 | Sabrin Blihi (3), Eva Codermatz, Ylenia Grech (2), Suzanne Farrugia Sacco (2)(R); own goal (M) |
| 23-Nov | Mgarr U. | vs | Kirkop U. | 0-1 | Shanelle Mazzitelli |
| 23-Nov | Birkirkara | vs | Senglea A. | 10-0 | Lucia Said (3), Sara Saliba (5), Michela Mifsud Gauci, Sharona Mallia |
| 23-Nov | Swieqi U. | vs | Zebbug R. | 2-0 | Kim Fava (2) |
| 30-Nov | Mtarfa | vs | Mosta | 0-5 | Fatma Al Girbi (3), Yulya Carella, Yasmin Sajeba |
| 30-Nov | Zebbug R. | vs | Kirkop U. | 2-1 | Ileana Farrugia, Alicia Mifsud (Z); Martina Spiteri (K) |
| 30-Nov | Raiders GFC | vs | Birkirkara | 4-5 | Ylenia Grech, Sarah Vella Barberi, Eva Codermatz, Sabrin Blihi (R); Sara Saliba (3), Amelia Vassallo, Stella Francalanza (B) |
| 30-Nov | Senglea A. | vs | Swieqi U. | 0-6 | Iulia Mifsud (2), Michaela Cachia (3), own goal |
| 07-Dec | Mosta | vs | Mgarr U. | 5-1 | Yasmin Sajeba (2), Ivana Schembri (2), Yulya Carella (Mos); Aaliyah Aquilina (Mga) |
| 07-Dec | Senglea A. | vs | Zebbug R. | 0-11 | Lana Montebello, Francesca Bartolo, Ileana Farrugia (4), Angie Borg (3), Ilania Agius (2) |
| 07-Dec | Birkirkara | vs | Mtarfa | 8-0 | Ylenia Azzopardi, Sara Saliba (4), Stella Francalanza, Kelly Chircop, Nilayza Attard |
| 07-Dec | Swieqi U. | vs | Raiders GFC | 3-1 | Iulia Mifsud (3)(S); Sarah Vella Barberi (R) |
| 18-Jan | Kirkop U. | vs | Mosta | 3-1 | Lauren Aquilina (2), Hailey Grech (K); Chanelle Fenech (M) |
| 18-Jan | Raiders GFC | vs | Senglea A. | 14-1 | Suzanne Farrugia Sacco (2), Eva Codermatz (2), Sarah Vella Barberi, Sabrin Blihi (3), Ylenia Grech (3) Megan La Rosa (2), own goal (R); Kaya Mizzi (S) |
| 18-Jan | Mgarr U. | vs | Birkirkara | 1-1 | Faith Schembri (M); Sara Saliba (B) |
| 18-Jan | Mtarfa | vs | Swieqi U. | 0-12 | Kim Fava (4), Michaela Cachia (3), Kaysia Micallef, Iulia Mifsud (3), Maria Vella |
| 25-Jan | Raiders GFC | vs | Zebbug R. | 3-4 | Suzanne Farrugia Sacco, Eva Codermatz (R); Ileana Farrugia, Alicia Mifsud (2), Estelle Borg (Z) |
| 25-Jan | Birkirkara | vs | Kirkop U. | 3-0 | Sara Saliba, Lexine Farrugia (2) |
| 25-Jan | Senglea A. | vs | Mtarfa | 2-1 | Shalaya Sammut, Brooke Stivala (S); Rihanna Micallef (M) |
| 25-Jan | Swieqi U. | vs | Mgarr U. | 2-0 | Kim Fava, Iulia Mifsud |
| 01-Feb | Zebbug R. | vs | Mosta | 8-2 | Lana Montebello (3), Ileana Farrugia (3), Francesca Bartolo (2)(Z); Ivana Schembri, Yulya Carella (M) |
| 01-Feb | Kirkop U. | vs | Swieqi U. | 1-4 | Kim Fava (2), Kaysia Micallef, Iulia Mifsud (S); Hailey Grech (K) |
| 01-Feb | Mtarfa | vs | Raiders GFC | 0-7 | Sabrin Blihi (2), Michela Micallef, Eva Codermatz (3), Suzanne Farrugia Sacco |
| 01-Feb | Mgarr U. | vs | Senglea A. | 8-0 | Faith Schembri (4), Luisa Maniscalco, Ruth Micallef (2), Kylie Micallef |
| 08-Feb | Mosta | vs | Birkirkara | 0-6 | Lexine Farrugia (3), Sara Saliba (2), Thea Tedesco |
| 25-Apr | Senglea A. | vs | Kirkop U. | ||
| 08-Feb | Mtarfa | vs | Zebbug R. | 0-17 | Ileana Farrugia (8), Francesca Bartolo (2), Angie Borg (6), Alicia Mifsud |
| 08-Feb | Raiders GFC | vs | Mgarr U. | 6-1 | Sabrin Blihi (2), Michela Micallef, Eva Codermatz, Ylenia Grech, Suzanne Farrugia Sacco (R); Faith Schembri (M) |
| 29-Feb | Swieqi U. | vs | Mosta | 12-0 | Iulia Mifsud (3), Kim Fava (5), Michaela Cachia (3), Ema Micallef |
| 29-Feb | Kirkop U. | vs | Raiders GFC | 0-3 | Eva Codermatz, Ylenia Grech, Sabrin Blihi |
| 29-Feb | Zebbug R. | vs | Birkirkara | 0-2 | Sara Saliba, Thea Tedesco |
| 29-Feb | Mgarr U. | vs | Mtarfa | 8-0 | Luisa Maniscalco, own goal, Ruth Micallef, Kayah Abela Sciberras, Yasmine Spiteri (2), Hannah Vella, Kylie Micallef |
| 07-Mar | Mosta | vs | Senglea A. | 4-1 | Rachel Cassar (S); Fatma Al Girbi (2), Yasmin Sajeba, Ivana Schembri (M) |
| 07-Mar | Mtarfa | vs | Kirkop U. | 0-10 | own goal (2), Federica Zahra, Hailey Grech (2), Martina Spiteri (5) |
| 07-Mar | Birkirkara | vs | Swieqi U. | 1-0 | Lexine Farrugia |
| 07-Mar | Mgarr U. | vs | Zebbug R. | 1-1 | Faith Schembri (M); Ileana Farrugia (Z) |
| Raiders GFC | vs | Mosta | Matches were initially postponed and later cancelled after a decision by the MFA Executive Committee to end all competitions on April 29 due to the COVID-19 pandemic. | ||
| Kirkop U. | vs | Mgarr U. | |||
| Senglea A. | vs | Birkirkara | |||
| Zebbug R. | vs | Swieqi U. | |||
| Mosta | vs | Mtarfa | |||
| Kirkop U. | vs | Zebbug R. | |||
| Birkirkara | vs | Raiders GFC | |||
| Swieqi U. | vs | Senglea A. | |||
| Mgarr U. | vs | Mosta | |||
| Zebbug R. | vs | Senglea A. | |||
| Mtarfa | vs | Birkirkara | |||
| Raiders GFC | vs | Swieqi U. | |||
| Mosta | vs | Kirkop U. | |||
| Senglea A. | vs | Raiders GFC | |||
| Birkirkara | vs | Mgarr U. | |||
| Swieqi U. | vs | Mtarfa | |||