| Date | Home | vs | Away | Result | Scorers |
| 24-Sep | San Gwann | vs | Sliema W. | 1-5 | Rowad Benhamed (2), Alex Satariano, Mark Desira, Mikail Camilleri (S); Adam Falzon (SG) |
| 23-Sep | Pieta’ H. | vs | Balzan | 0-2 | Daniel Atzori, Pedro Augusto Mota de Lima |
| 23-Sep | Mosta | vs | Valletta | 2-1 | Christ Evo Ememe (2)(M); Jeremy Micallef (V) |
| 23-Sep | St. Andrews | vs | Birkirkara | 0-1 | Jacques Vella Critien |
| 23-Sep | Melita | vs | Hamrun S. | 1-0 | Brandon Agius |
| 30-Sep | Birkirkara | vs | Mosta | 1-4 | Carlo Zammit Lonardelli (B); Gianluca Sciberras, Liam Portelli (2), Jordan Vella (M) |
| 30-Sep | Valletta | vs | Pieta’ H. | 1-1 | own goal (P); Isaiah Micallef (V) |
| 30-Sep | Sliema W. | vs | St. Andrews | 7-0 | Jean Borg (5), Mohamed Abuda (2) |
| 01-Oct | Balzan | vs | Melita | 2-0 | Pedro Augusto Mota (2) |
| 01-Oct | Hamrun S. | vs | San Gwann | 1-0 | Christopher Galea |
| 28-Oct | Mosta | vs | Pieta’ H. | 0-0 | |
| 28-Oct | St. Andrews | vs | Hamrun S. | 4-0 | Liam Hudson, Mattia Veselji (2), Sean Ellul |
| 28-Oct | Melita | vs | Valletta | 0-2 | Jeremy Micallef, Ryan Tonna |
| 28-Oct | San Gwann | vs | Balzan | 0-3 | Zak Grech, Pedro Augusto Mota, Marcus Grima |
| 29-Oct | Birkirkara | vs | Sliema W. | 1-1 | Michele Alessandro Vella (B); Alex Satariano (S) |
| 04-Nov | Melita | vs | Pieta’ H. | 4-1 | Matthew Debattista, Liam Delicata (2), Eman Falzon (M); Jake Bone (P) |
| 04-Nov | Sliema W. | vs | Mosta | 1-3 | Matthew Attard, Christ Evo Ememe, own goal (M); Alexander Spiteri (S) |
| 05-Nov | Valletta | vs | San Gwann | 3-2 | Ryan Tonna (3)(V); Alessio Galea, Jean Paul Attard (SG) |
| 04-Nov | St. Andrews | vs | Balzan | 0-4 | Adam Bradshaw, own goals (2), Marcus Grima |
| 06-Nov | Hamrun S. | vs | Birkirkara | 0-6 | Carlo Zammit Lonardelli (2), Andrew Messina, Paul Mbong (2), Angelo Migliore |
| 29-Nov | Mosta | vs | Melita | 3-1 | Christ Evo Ememe, Usman Dahiru Mohammed, Jordan Vella (Mos); Matthew Debattista (Mel) |
| 25-Nov | St. Andrews | vs | Valletta | 0-1 | Tsotne Jintcharadze |
| 29-Nov | Sliema W. | vs | Hamrun S. | 0-0 | |
| 27-Nov | San Gwann | vs | Pieta’ H. | 0-3 | Jeremy Delmar (2), Liam Mckay |
| 27-Nov | Birkirkara | vs | Balzan | 0-1 | Pedro Augusto Mota |
| 09-Dec | Pieta’ H. | vs | St. Andrews | 5-1 | Jeremy Delmar (2), Liam Scicluna, Kurt Mifsud, Clyde Bouvet (P); Mattia Veselji (SA) |
| 09-Dec | Valletta | vs | Birkirkara | 2-0 | Samuel Vella, Kenley Scerri |
| 09-Dec | Balzan | vs | Sliema W. | 6-0 | Adrian Domingo Vilda (4), Zak Grech, David Boham Habiganuchi |
| 10-Dec | Melita | vs | San Gwann | 4-0 | Eman Falzon (4) |
| 09-Dec | Hamrun S. | vs | Mosta | 1-2 | Xylon Portelli (H); Jordan Vella, Christ Evo Ememe (M) |
| 16-Dec | St. Andrews | vs | Melita | 2-0 | Mattia Veselji, William James England |
| 17-Dec | Birkirkara | vs | Pieta’ H. | 1-2 | Paul Mbong (B); Jeremy Delmar, Liam Mckay (P) |
| 18-Dec | Mosta | vs | San Gwann | 2-0 | Christ Ememe, Luke Formosa |
| 18-Dec | Sliema W. | vs | Valletta | 3-1 | Alex Satariano (3)(S); Tsotne Jintcharadze (V) |
| 18-Dec | Hamrun S. | vs | Balzan | 0-3 | Adrian Domingo Vilda, Jake Saliba (2) |
| 06-Jan | Balzan | vs | Mosta | 3-0 | Zak Grech (2), Marcus Grima |
| 06-Jan | Valletta | vs | Hamrun S. | 1-1 | Kieran Higgans (H); Jean Leon Cassar (V) |
| 06-Jan | Pieta’ H. | vs | Sliema W. | 4-0 | Liam Mckay, Jake Bone, Emerson Camilleri, Liam Scicluna |
| 06-Jan | Melita | vs | Birkirkara | 3-2 | Eman Falzon, Matthias Vella, Liam Delicata (M); Paul Mbong, Carlo Zammit Lonardelli (B) |
| 07-Jan | San Gwann | vs | St. Andrews | 2-0 | Matthew Xuereb, Nathan Sultana |
| 13-Jan | Sliema W. | vs | Melita | 2-5 | Alex Satariano (2)(S); own goal, Liam Delicata, Karl Mohnani, Brandon Agius, Jake Engerer (M) |
| 13-Jan | Balzan | vs | Valletta | 0-1 | Shaun Dimech |
| 13-Jan | Birkirkara | vs | San Gwann | 0-2 | Ian Caruana, Matthew Xuereb |
| 14-Jan | Mosta | vs | St. Andrews | 1-1 | Gianluca Sciberras (M); Russell Micallef (SA) |
| 15-Jan | Hamrun S. | vs | Pieta’ H. | 0-1 | Kurt Mifsud |
| 20-Jan | Birkirkara | vs | St. Andrews | 0-0 | |
| 20-Jan | Hamrun S. | vs | Melita | 1-0 | Neil Demanuele |
| 21-Jan | Balzan | vs | Pieta’ H. | 0-2 | Sheldon Pisani, Jake Bone |
| 22-Jan | Sliema W. | vs | San Gwann | 0-5 | Andrea Zammit, Christian Gauci, Jean Paul Attard, Liam Borg, Dale Mifsud |
| 22-Jan | Valletta | vs | Mosta | 0-1 | Miguel Aquilina |
| 03-Feb | Pieta’ H. | vs | Valletta | 3-2 | Kurt Mifsud, Liam Mckay, own goal (P); Christopher Cutajar, Joshua Micallef (V) |
| 03-Feb | San Gwann | vs | Hamrun S. | 1-0 | Ian Caruana |
| 04-Feb | Mosta | vs | Birkirkara | 2-0 | David Ifeanyi Onyeanula, Gianluca Tanti |
| 03-Feb | St. Andrews | vs | Sliema W. | 2-1 | Jack Kind (SW); Sean Ellul (2)(SA) |
| 04-Feb | Melita | vs | Balzan | 2-1 | Brandon Agius, Nicholas Jaccarini (M); Kyle Sciberras Balbi (B) |
| 11-Feb | Pieta’ H. | vs | Mosta | 0-0 | |
| 11-Feb | Sliema W. | vs | Birkirkara | 1-0 | Alexander Spiteri |
| 11-Feb | Hamrun S. | vs | St. Andrews | 0-2 | Jamie Sixsmith, Mattia Veselji |
| 12-Feb | Valletta | vs | Melita | 4-2 | Ryan Tonna, Christopher Cutajar, Kieran Paul Fenech, Samuel Vella (V); Liam Delicata, Karl Mohnani (M) |
| 12-Feb | Balzan | vs | San Gwann | 1-0 | Zak Grech |
| 17-Feb | Mosta | vs | Sliema W. | 3-0 | Christ Evo Ememe, Matteo Vella, David Ifenayi Onyeanula |
| 18-Feb | Balzan | vs | St. Andrews | 3-0 | Marcus Grima, Adrian Domingo Vilda, Zak Grech |
| 17-Feb | San Gwann | vs | Valletta | 0-3 | Joshua Micallef, Jeremy Micallef, Ryan Tonna |
| 18-Feb | Hamrun S. | vs | Birkirkara | 1-0 | Miguel Tabone |
| 19-Feb | Pieta’ H. | vs | Melita | 2-4 | Emerson Camilleri, Jeremy Delmar (P); Eman Falzon, Jake Engerer (2), Karl Mohnani (M) |
| 24-Feb | Melita | vs | Mosta | 0-6 | Jordan Vella (3), David Ifeanyi Onyeanula, Christ Evo Ememe, Luke Formosa |
| 24-Feb | Balzan | vs | Birkirkara | 3-1 | Adrian Domongo Vilda, David Boham Habiganuchi, Isaac Buhagiar (B); Owen Sciberras (B) |
| 25-Feb | Pieta’ H. | vs | San Gwann | 1-2 | Jean Paul Attard, Ian Caruana (SG); Jeremy Delmar (P) |
| 25-Feb | Hamrun S. | vs | Sliema W. | 1-2 | Miguel Tabone (H); Alexander Spiteri, Alexander Satariano (S) |
| 26-Feb | Valletta | vs | St. Andrews | 1-0 | Kenley Scerri |
| 02-Mar | Sliema W. | vs | Balzan | 0-6 | Adrian Domingo Vilda, Pedro Augusto Mota (4), Jake Saliba |
| 02-Mar | Birkirkara | vs | Valletta | 0-0 | |
| 03-Mar | Mosta | vs | Hamrun S. | 1-0 | Christ Evo Ememe |
| 02-Mar | St. Andrews | vs | Pieta’ H. | 3-3 | Mattia Veselji (2), Jamie Sixsmith (SA); Kurt Galea, Zean Leonardi, Jamie Scerri (P) |
| 04-Mar | San Gwann | vs | Melita | 1-2 | Matthew Debattista, Brandon Agius (M); Andrea Zammit (SG) |
| Pieta’ H. | vs | Birkirkara | Matches were initially postponed and later cancelled after a decision by the MFA Executive Committee to end all competitions on April 29 due to the COVID-19 pandemic. | ||
| Valletta | vs | Sliema W. | |||
| Balzan | vs | Hamrun S. | |||
| Melita | vs | St. Andrews | |||
| San Gwann | vs | Mosta | |||
| Birkirkara | vs | Melita | |||
| Sliema W. | vs | Pieta’ H. | |||
| Mosta | vs | Balzan | |||
| St. Andrews | vs | San Gwann | |||
| Hamrun S. | vs | Valletta | |||
| Pieta’ H. | vs | Hamrun S. | |||
| Valletta | vs | Balzan | |||
| St. Andrews | vs | Mosta | |||
| Melita | vs | Sliema W. | |||
| San Gwann | vs | Birkirkara | |||