| Date | Home | vs | Away | Result | Scorers |
| 02-Sep | Floriana | vs | Attard | 3-5 | Aleandro Garzia (2), Bradley Sciberras (F); Lydon Cuschieri (2), Kyle Zarb, Jamie Delia, Mark Cutajar (A) |
| 02-Sep | Mellieha | vs | Tarxien R. | 0-3 | Cedric Zahra, own goal, Dale Tabone |
| 03-Sep | Luqa SA | vs | Kirkop U. | 4-1 | Andrew Cachia (K); Mario Jude Dominicius (2), Ronan Cassar, Alan Abdelrahman (L) |
| 03-Sep | Sirens | vs | Birzebbuga SP | 0-1 | Sam Kind |
| 04-Sep | Pembroke A. | vs | Marsaxlokk | 4-2 | Denilson Borg Castaldi, Kieran Curmi (M); Neil Frendo (3), Isaac Buhagiar (P) |
| 09-Sep | Birzebbuga SP | vs | Pembroke A. | 2-3 | Nathan Camilleri, Christian Camilleri, Larkin Attard (P); Sam Kind (2)(B) |
| 10-Sep | Attard | vs | Mellieha | 1-0 | Jeremy George Azzopardi |
| 09-Sep | Tarxien R. | vs | Luqa SA | 0-4 | Matthew Schembri (2), own goal, Dario Aquilina |
| 10-Sep | Marsaxlokk | vs | Floriana | 0-4 | Bradley Sciberras, Aleandro Garzia, Erson Schembri, Brandon Bray |
| 10-Sep | Kirkop U. | vs | Sirens | 3-0 | Jake Buhagiar, Darren Darmanin (2) |
| 16-Sep | Kirkop U. | vs | Tarxien R. | 2-3 | Kurt Borg, Cedric Zahra, Dale Tabone (T); own goal, Isaac Portelli (K) |
| 16-Sep | Sirens | vs | Pembroke A. | 0-2 | Bernard Caruana, Neil Frendo |
| 25-Sep | Floriana | vs | Birzebbuga SP | 1-1 | Sam Kind (B); Mattias Formosa (F) |
| 25-Sep | Mellieha | vs | Marsaxlokk | 0-1 | Denilson Borg Castaldi |
| 26-Sep | Luqa SA | vs | Attard | 0-1 | Kyle Zarb |
| 07-Oct | Birzebbuga SP | vs | Mellieha | 3-1 | Sam Kind (2), Owen Micallef (B); Miguel Camilleri (M) |
| 07-Oct | Attard | vs | Kirkop U. | 2-0 | Kieron Haber, Jamie Delia |
| 30-Oct | Marsaxlokk | vs | Luqa SA | 0-5 | Mario Jude Dominicus (2), Alan Abdel Rahman, own goal, Matthew Schembri |
| 08-Oct | Pembroke A. | vs | Floriana | 1-3 | Aleandro Sultana (P); Mattias Formosa, Erson Schembri, Zack Camilleri (F) |
| 08-Oct | Tarxien R. | vs | Sirens | 5-0 | Cedric Zahra (2), Kurt Borg, Luigi Bonavia, Manuel Farrugia |
| 21-Oct | Mellieha | vs | Pembroke A. | 1-0 | Michael Micallef |
| 21-Oct | Kirkop U. | vs | Marsaxlokk | 2-0 | Gian Piero Tozzolino, Omar Khatib |
| 21-Oct | Sirens | vs | Floriana | 0-3 | Brandon Bray, Isaac Galea, Mattias Formosa |
| 23-Oct | Tarxien R. | vs | Attard | 3-4 | Lydon Cuschieri (2), Adrian Paul Sammut, Julian Farrugia (A); Keith Attard, Petar Kanzurov, Dale Tabone (T) |
| 23-Oct | Luqa SA | vs | Birzebbuga SP | 2-2 | Alan Abdel Rahman, Matthew Schembri (L); Sam Kind (2)(B) |
| 29-Oct | Birzebbuga SP | vs | Kirkop U. | 2-3 | Reuben Scicluna, Matthias Mizzi, Miguel Calleja (K); Sam Kind (2)(B) |
| 06-Nov | Marsaxlokk | vs | Tarxien R. | 2-6 | Christian Desira, Kurt Borg, Petar Kanzurov (3), Keith Attard (T); Jordi Casha, Denilson Borg Castaldi (M) |
| 06-Nov | Attard | vs | Sirens | 4-0 | Lydon Cuschieri (4) |
| 07-Nov | Floriana | vs | Mellieha | 1-0 | Brandon Bray |
| 07-Nov | Pembroke A. | vs | Luqa SA | 1-1 | Larkin Attard (P); Nathan Frendo (L) |
| 10-Dec | Tarxien R. | vs | Birzebbuga SP | 1-2 | Nathaniel Camilleri, Sam Kind (B); Dale Tabone (T) |
| 11-Nov | Kirkop U. | vs | Pembroke A. | 0-5 | Kurt Zammit, Darko Todorovski (2), Liam Camilleri (2) |
| 19-Dec | Attard | vs | Marsaxlokk | 5-1 | Lydon Cuschieri (3), Kieran Mallia, Sven Bartolo (A); Thomas Vassallo Mintoff (M) |
| 11-Dec | Sirens | vs | Mellieha | 0-2 | Filip Minev (2) |
| 11-Dec | Luqa SA | vs | Floriana | 1-3 | Brandon Bray (2), Erson Schembri (F); Mario Jude Dominicus (L) |
| 22-Jan | Birzebbuga SP | vs | Attard | 1-2 | Lydon Cuschieri, Jake Micallef (A); own goal (B) |
| 21-Nov | Floriana | vs | Kirkop U. | 0-0 | |
| 20-Nov | Marsaxlokk | vs | Sirens | 2-0 | Kieran Curmi, Miguel Mifsud |
| 20-Nov | Mellieha | vs | Luqa SA | 1-4 | Mario Jude Dominicus (2), Dario Aquilina, Matthew Schembri (L); Steve Farrugia (M) |
| 21-Nov | Pembroke A. | vs | Tarxien R. | 3-2 | Kurt Borg (2)(T); Darko Todorovski (2), Samuel Camilleri (P) |
| 27-Nov | Marsaxlokk | vs | Birzebbuga SP | 2-0 | Rhys Mifsud (2) |
| 28-Nov | Tarxien R. | vs | Floriana | 0-0 | |
| 27-Nov | Kirkop U. | vs | Mellieha | 2-3 | Gian Piero Tozzolino, Owar Khatib (K); Giuseppe Galea Curmi, Thomas Vella, Michael Micallef (M) |
| 28-Nov | Sirens | vs | Luqa SA | 1-2 | Mario Jude Dominicus, Ronan Cassar (L); Kayode Zammit (S) |
| 12-Dec | Attard | vs | Pembroke A. | 0-1 | Christian Camilleri |
| 18-Dec | Birzebbuga SP | vs | Sirens | 1-0 | Sam Kind |
| 21-Jan | Marsaxlokk | vs | Pembroke A. | 2-0 | Steven Grima, Niko Aquilina |
| 18-Dec | Tarxien R. | vs | Mellieha | 1-1 | Steve Farrugia (M); Mihajlo Jelic (T) |
| 19-Dec | Kirkop U. | vs | Luqa SA | 0-2 | Nathan Frendo, Miguel Pace |
| 08-Jan | Attard | vs | Floriana | 4-2 | Lydon Cushieri, Adrian Paul Sammut, Sven Bartolo, Kieron Haber (A); Bradley Sciberras, Aleandro Garzia (F) |
| 15-Jan | Floriana | vs | Marsaxlokk | 0-1 | Denilson Borg Castaldi |
| 15-Jan | Mellieha | vs | Attard | 0-2 | own goal, Adrian Paul Sammut |
| 15-Jan | Pembroke A. | vs | Birzebbuga SP | 1-1 | own goal (P); Sam Kind (B) |
| 15-Jan | Luqa SA | vs | Tarxien R. | 0-2 | Mihajlo Jelic, Dale Tabone |
| 16-Jan | Sirens | vs | Kirkop U. | 1-4 | Reuben Scicluna, Giorgio Bellia, Gian Piero Tozzolino, Johann Vassallo (K); Ognjen Ilic (S) |
| 05-Feb | Birzebbuga SP | vs | Floriana | 0-0 | |
| 05-Feb | Pembroke A. | vs | Sirens | 2-0 | Darko Todorovski (2) |
| 06-Feb | Marsaxlokk | vs | Mellieha | 6-2 | Dario Aquilina (2), Denilson Borg Castaldi, Joseph Duran Rodriguez, Jordi Casha, own goal (Mxl); Thomas Vella, Miguel Camilleri (Mel) |
| 11-Feb | Tarxien R. | vs | Kirkop U. | 4-1 | Petar Kanzurov, Ryohei Fujimura, Nevin Portelli, own goal (K); Omar Khatib (K) |
| 13-Feb | Attard | vs | Luqa SA | 3-0 | Adrian Paul Sammut, Lydon Cuschieri (2) |
| 19-Feb | Mellieha | vs | Birzebbuga SP | 1-0 | Michael Micallef |
| 19-Feb | Luqa SA | vs | Marsaxlokk | 1-0 | Mario Jude Dominicus |
| 20-Feb | Kirkop U. | vs | Attard | 2-2 | Lydon Cuschieri, Jake MIcallef (A); Omar Khatib, Darren Darmanin (K) |
| 26-Feb | Sirens | vs | Tarxien R. | 1-4 | Petar Kanzurov, Ryohei Fujimura (2), Jurgen Mallia (T); Ognjen Ilic (S) |
| 27-Feb | Floriana | vs | Pembroke A. | 3-1 | Brandon Bray, Malcolm Agius, Bradley Sciberras (F); Matthew Buhagiar (P) |
| 02-Mar | Attard | vs | Tarxien R. | 2-2 | Nevin Portelli, Petar Kanzurov (A); Jeremy George Azzopardi, Lydon Cuschieri (T) |
| 04-Mar | Marsaxlokk | vs | Kirkop U. | 7-1 | Niko Aquilina (4), Dario Aquilina, Denilson Borg Castaldi (2), Joseph Duran Rodriguez (M); Darren Darmanin (K) |
| 11-Mar | Birzebbuga SP | vs | Luqa SA | 2-2 | Mario Jude Dominicus, Alan Abdel Rahman (L); Brandon Magro, Nathaniel Camilleri (B) |
| 04-Mar | Floriana | vs | Sirens | 4-0 | Kurt Theuma, Mattias Formosa, Zack Camilleri, Bradley Sciberras |
| 11-Mar | Pembroke A. | vs | Mellieha | 2-0 | Larkin Attard, Daniel Vella |
| Tarxien R. | vs | Marsaxlokk | Matches were initially postponed and later cancelled after a decision by the MFA Executive Committee to end all competitions on April 29 due to the COVID-19 pandemic. | ||
| Sirens | vs | Attard | |||
| Mellieha | vs | Floriana | |||
| Luqa SA | vs | Pembroke A. | |||
| Kirkop U. | vs | Birzebbuga SP | |||
| Birzebbuga SP | vs | Tarxien R. | |||
| Floriana | vs | Luqa SA | |||
| Marsaxlokk | vs | Attard | |||
| Mellieha | vs | Sirens | |||
| Pembroke A. | vs | Kirkop U. | |||
| Tarxien R. | vs | Pembroke A. | |||
| Attard | vs | Birzebbuga SP | |||
| Luqa SA | vs | Mellieha | |||
| Sirens | vs | Marsaxlokk | |||
| Kirkop U. | vs | Floriana | |||
| Luqa SA | vs | Sirens | |||
| Mellieha | vs | Kirkop U. | |||
| Birzebbuga SP | vs | Marsaxlokk | |||
| Floriana | vs | Tarxien R. | |||
| Pembroke A. | vs | Attard | |||