| Date | Home | vs | Away | Result | Scorers |
| 23-Aug | Sirens | vs | Senglea A. | 1-1 | Emmanuel Okoye (Sir); Jose Wilkson Teixeira (Sen) |
| 23-Aug | Valletta | vs | Santa Lucia | 2-3 | Wilkerson Batata (2), Rei Tachikawa (SL); Mario Fontanella, Kyrian Nwoko (V) |
| 23-Aug | Gzira U. | vs | Hamrun S. | 0-0 | |
| 23-Aug | Birkirkara | vs | Floriana | 0-1 | Kristian Keqi |
| 24-Aug | Gudja U. | vs | Hibernians | 1-1 | own goal (G); Jake Grech (H) |
| 24-Aug | Tarxien R. | vs | Mosta | 0-4 | Tyrone Farrugia, Nikita Kotlov, Edin Murga, Momodou Salieu Jallow |
| 24-Aug | Balzan | vs | Sliema W. | 2-1 | Nenad Sljivic, Stefan Dimic (B); Jean Paul Farrugia (S) |
| 28-Aug | Senglea A. | vs | Birkirkara | 1-0 | Wilfried Zamble bi Koihi |
| 28-Aug | Hibernians | vs | Tarxien R. | 4-1 | Aleksa Andrejic (T); Leonardo Nanni (2), Terrence Groothusen, Joseph Mbong (H) |
| 29-Aug | Floriana | vs | Balzan | 1-0 | Kristian Keqi |
| 29-Aug | Sliema W. | vs | Valletta | 1-3 | Enmy Pena Beltre, Matteo Piciollo, Yuri de Jesus Messias (V); Juri Cisotti (S) |
| 30-Aug | Mosta | vs | Sirens | 3-4 | Abdullahi Ige Adeshina, Emmanuel Okoye, Flavio Cheveresan, Wellington de Oliveira (S); Momodou Jallow, Matias Muchardi, Weverton Gomes (M) |
| 30-Aug | Santa Lucia | vs | Gzira U. | 0-0 | |
| 30-Aug | Hamrun S. | vs | Gudja U. | 2-2 | Marco Criaco, Ryan Darmanin (H); Juan Andres Bolano, Rundell Winchester (G) |
| 13-Sep | Tarxien R. | vs | Hamrun S. | 2-3 | Wilfried Domoraud (2), Soufiane Lagzir (H); Thomas Veronese, Aleksa Andrejic (T) |
| 14-Sep | Sirens | vs | Hibernians | 2-1 | Thiago Espindola de Paula, Flavio Cheveresan (S); own goal (H) |
| 14-Sep | Senglea A. | vs | Mosta | 2-1 | Nikita Kotlov (M); Taisei Marukawa, Wilfried Zamble (S) |
| 14-Sep | Gzira U. | vs | Sliema W. | 1-1 | Jefferson de Assis (G); Juri Cisotti (S) |
| 14-Sep | Birkirkara | vs | Balzan | 3-3 | Luke Montebello, Ricardo Calixto Correa, Kristijan Naumovski (Bal); Federico Falcone, Miguel Angel Alba (2)(Bkr) |
| 15-Sep | Gudja U. | vs | Santa Lucia | 1-1 | Kevin Ante Rosero (SL); Alexandre Santana (G) |
| 15-Sep | Valletta | vs | Floriana | 1-1 | Kristian Keqi (F); Enmy Pena Beltre (V) |
| 20-Sep | Mosta | vs | Birkirkara | 1-1 | Edin Murga (M); Miguel Angel Alba (B) |
| 21-Sep | Hamrun S. | vs | Sirens | 4-0 | Soufiane Lagzir (2), Wilfried Domoraud, Nicola Leone |
| 21-Sep | Sliema W. | vs | Gudja U. | 1-1 | Claudio Zappa (S); Aiden Friggieri (G) |
| 21-Sep | Hibernians | vs | Senglea A. | 2-1 | Leonardo Nanni, Terrence Groothusen (H); Jose Wilkson Teixeira (S) |
| 21-Sep | Balzan | vs | Valletta | 0-2 | Bojan Kaljevic, Irakli Dzaria |
| 22-Sep | Santa Lucia | vs | Tarxien R. | 2-1 | Rei Tachikawa, Jackson David Usuga Mendoza (SL); Thomas Veronese (T) |
| 22-Sep | Floriana | vs | Gzira U. | 0-0 | |
| 27-Sep | Tarxien R. | vs | Sliema W. | 1-2 | Claudio Zappa, Seydou Sow (S); Aleksa Andrejic (T) |
| 28-Sep | Gudja U. | vs | Floriana | 0-2 | Tiago Adan Fonseca (2) |
| 28-Sep | Sirens | vs | Santa Lucia | 3-1 | Abdullahi Ige Adeshina (2), Wellington de Oliveira (Sir); Luis Diego Mosquera Segura (StL) |
| 28-Sep | Senglea A. | vs | Hamrun S. | 1-3 | Valdo Alhinho Goncalves, Marco Criaco, Soufiane Lagzir (H); Leighton Grech (S) |
| 28-Sep | Birkirkara | vs | Valletta | 2-2 | Steve Borg, Enmy Pena Beltre (V); Caio Henrique Prado, Miguel Angel Alba (B) |
| 29-Sep | Mosta | vs | Hibernians | 1-2 | Terrence Groothusen, Jake Grech (H); Rafael Morisco (M) |
| 29-Sep | Gzira U. | vs | Balzan | 2-0 | Andrew Cohen, Jefferson de Assis |
| 05-Oct | Hibernians | vs | Birkirkara | 0-1 | Federico Falcone |
| 05-Oct | Balzan | vs | Gudja U. | 1-0 | Arthur Faria Machado |
| 03-Oct | Valletta | vs | Gzira U. | 1-3 | Amadou Samb, Jefferson de Assis (2)(G); Mario Fontanella (V) |
| 05-Oct | Santa Lucia | vs | Senglea A. | 0-0 | |
| 05-Oct | Sliema W. | vs | Sirens | 0-1 | Flavio Cheveresan |
| 06-Oct | Floriana | vs | Tarxien R. | 2-1 | Manuel Murillo Torres (T); Jan Busuttil Kristian Keqi (F) |
| 06-Oct | Hamrun S. | vs | Mosta | 0-2 | Nikita Kotlov (2) |
| 18-Oct | Mosta | vs | Santa Lucia | 1-0 | Momodou Jallow Salieu |
| 18-Oct | Senglea A. | vs | Sliema W. | 2-0 | Wilfried Zamble, Taisei Marukawa |
| 19-Oct | Sirens | vs | Floriana | 1-4 | Wellington de Oliveira (S); Diego Venancio, Tiago Adan Fonseca, Brandon Paiber, Kristian Keqi (F) |
| 20-Oct | Tarxien R. | vs | Balzan | 1-3 | Andrija Majdevac (2), Alfred Effiong (B); Destin Mambouana (T) |
| 20-Oct | Gudja U. | vs | Valletta | 0-1 | Mario Fontanella |
| 19-Oct | Birkirkara | vs | Gzira U. | 1-3 | Hamed Kone (2), Andrew Cohen (G); Federico Falcone (B) |
| 21-Oct | Hibernians | vs | Hamrun S. | 1-2 | Jorge Ailton Soares (2)(HS); Dunstan Vella (Hib) |
| 26-Oct | Gzira U. | vs | Gudja U. | 6-1 | Jefferson de Assis (4), Amadou Samb, Andrew Cohen (Gzi); Aiden Friggieri (Gud) |
| 28-Oct | Santa Lucia | vs | Hibernians | 0-2 | Imanol Iriberri (2) |
| 25-Oct | Floriana | vs | Senglea A. | 5-0 | Kristian Keqi (2), Matias Garcia, Tiago Adan Fonseca, Terence Vella |
| 26-Oct | Valletta | vs | Tarxien R. | 3-1 | Kyrian Nwoko, Mario Fontanella, Douglas Packer (V); Stiv Shaba (T) |
| 27-Oct | Balzan | vs | Sirens | 2-4 | Romario Lucas Menezes, Thiago Espindola de Paula, Emmanuel Okoye (2)(S); Ricardo Calixto, Correa, Andrija Majdevac (B) |
| 27-Oct | Hamrun S. | vs | Birkirkara | 0-0 | |
| 25-Oct | Sliema W. | vs | Mosta | 0-1 | Dexter Xuereb |
| 01-Nov | Tarxien R. | vs | Gzira U. | 0-5 | Martin Davis, Andrew Cohen, Amadou Samb (2), Hamed Kone |
| 01-Nov | Hamrun S. | vs | Santa Lucia | 1-1 | Wilfried Domoraud (H); Jamie Zerafa (SL) |
| 02-Nov | Senglea A. | vs | Balzan | 2-2 | Andrija Majdevac (2)(B); Manolito Micallef, Jose Wilkson Teixeira (S) |
| 02-Nov | Mosta | vs | Floriana | 1-3 | Kristian Keqi, Brandon Paiber (2)(F); Nikita Kotlov (M) |
| 03-Nov | Hibernians | vs | Sliema W. | 1-0 | Dunstan Vella |
| 03-Nov | Sirens | vs | Valletta | 0-0 | |
| 04-Nov | Birkirkara | vs | Gudja U. | 2-3 | Gabriel Mensah (2), Rundell Winchester (G); Federico Falcone (2)(B) |
| 10-Nov | Floriana | vs | Hibernians | 2-2 | Bjorn Kristensen, Jake Grech (H); Ryan Camenzuli, Kristian Keqi (F) |
| 08-Nov | Valletta | vs | Senglea A. | 1-0 | Matteo Piciollo |
| 08-Nov | Balzan | vs | Mosta | 5-0 | Uros Ljubomirac, Augustine Loof, Andrija Majdevac (2), Ricardo Calixto Correa |
| 09-Nov | Gudja U. | vs | Tarxien R. | 3-2 | Rundell Winchester, own goal, Miguel Antonio Jimenez (G); Aleksa Andrejic (2)(T) |
| 09-Nov | Santa Lucia | vs | Birkirkara | 0-2 | Edison Luis dos Santos (2) |
| 10-Nov | Gzira U. | vs | Sirens | 0-1 | Flavio Cheveresan |
| 08-Nov | Sliema W. | vs | Hamrun S. | 2-0 | Robert Johan Carvajal Diaz, Kurt Shaw |
| 22-Nov | Hamrun S. | vs | Floriana | 0-0 | |
| 23-Nov | Santa Lucia | vs | Sliema W. | 0-4 | own goal, Claudio Zappa, Peter Xuereb, Juri Cisotti |
| 24-Nov | Mosta | vs | Valletta | 0-4 | Irakli Dzaria, Mario Fontanella (2), Kevin Tulimieri |
| 23-Nov | Sirens | vs | Gudja U. | 1-1 | Romario Lucas Memezes (S); Miguel Antonio Jimenez (G) |
| 24-Nov | Hibernians | vs | Balzan | 2-1 | Imanol Iriberri (2)(H); Steve Pisani (B) |
| 25-Nov | Birkirkara | vs | Tarxien R. | 3-0 | Isaac Toah Ntow, Federico Falcone, Caio Henrique Prado |
| 25-Nov | Senglea A. | vs | Gzira U. | 1-3 | Gonzalo Nicolas Virano (S); Rodolfo Soares, Jefferson de Assis, Gianmarco Conti (G) |
| 06-Dec | Balzan | vs | Hamrun S. | 1-1 | Andrija Majdevac (B); Ailton Jorge dos Santos Soares (H) |
| 07-Dec | Gzira U. | vs | Mosta | 3-1 | Jefferson de Assis, Amadou Samb, Hamed Kone (G); Nikita Kotlov (M) |
| 07-Dec | Gudja U. | vs | Senglea A. | 4-1 | Gonzalo Nicolas Virano (S); Allan Ricardo Miranda, Gabriel Mensah, James Brincat (2) (G) |
| 07-Dec | Sliema W. | vs | Birkirkara | 2-1 | Caio Henrique Prado (B); Jean Paul Farrugia, Juri Cisotti (S) |
| 08-Dec | Valletta | vs | Hibernians | 1-1 | Mario Fontanella (V); Leonardo Nanni (H) |
| 08-Dec | Tarxien R. | vs | Sirens | 0-3 | Romario Lucas Memezes (2), Emmanuel Okoye |
| 07-Dec | Floriana | vs | Santa Lucia | 2-1 | Diego Venancio da Silva, Tiago Adan Fonseca (F); Adam Magri Overend (SL) |
| 16-Dec | Senglea A. | vs | Tarxien R. | 2-2 | Wilfried Zamble, Jose Wilkson Teixeira (S); Miguel Ciantar, Destin Mambouana (T) |
| 08-Jan | Mosta | vs | Gudja U. | 1-0 | Dexter Xuereb |
| 15-Dec | Sliema W. | vs | Floriana | 1-2 | Tiago Adan Fonseca, Jan Busuttil (F); John Mintoff (S) |
| 13-Dec | Birkirkara | vs | Sirens | 2-0 | Federico Falcone, own goal |
| 13-Dec | Hibernians | vs | Gzira U. | 2-0 | Andrei Agius, Jurgen Degabriele |
| 13-Dec | Santa Lucia | vs | Balzan | 0-3 | Andrija Majdevac (3) |
| 15-Dec | Hamrun S. | vs | Valletta | 0-1 | Mario Fontanella |
| 11-Jan | Santa Lucia | vs | Valletta | 2-2 | own goal, Camilo del Castillo Escobar (SL); Bojan Kaljevic, Mario Fontanella (V) |
| 11-Jan | Mosta | vs | Tarxien R. | 5-2 | Matthew Tabone, Aleksa Andrejic (T); Zachary Brincat (2), Dexter Xuereb, Weverton Gomes (2)(M) |
| 11-Jan | Senglea A. | vs | Sirens | 2-2 | Marcelo Dias, Ricardo Theodoro de Almeida (Sen); Romario Lucas Memezes, Edward Herrera (Sir) |
| 11-Jan | Sliema W. | vs | Balzan | 1-2 | Uros Ljubomirac, Luke Montebello (B); Claudio Zappa (S) |
| 12-Jan | Hibernians | vs | Gudja U. | 2-0 | Jurgen Degabriele, Imanol Iriberri |
| 12-Jan | Floriana | vs | Birkirkara | 0-1 | Federico Falcone |
| 13-Jan | Hamrun S. | vs | Gzira U. | 0-3 | Hamed Kone, Wilfried Domoraud, Martin Davis |
| 18-Jan | Gudja U. | vs | Hamrun S. | 1-1 | Soufiane Lagzir (H); Anderson de Barros (G) |
| 18-Jan | Birkirkara | vs | Senglea A. | 1-1 | Federico Falcone (B); Jose Wilkson Teixeira (S) |
| 18-Jan | Tarxien R. | vs | Hibernians | 0-4 | Imanol Iriberri (2), Jake Grech, Jurgen Degabriele |
| 18-Jan | Balzan | vs | Floriana | 1-3 | own goal (B); Augusto Rene Caseres, Tiago Adan Fonseca, Kristian Keqi (F) |
| 19-Jan | Sirens | vs | Mosta | 2-0 | Ricardo Silva Faria (2) |
| 19-Jan | Gzira U. | vs | Santa Lucia | 1-2 | Rei Tachikawa (2)(SL); Zach Scerri (G) |
| 20-Jan | Valletta | vs | Sliema W. | 2-1 | Rowen Muscat, Mario Fontanella (V); Federico Vasilchik (S) |
| 01-Feb | Sliema W. | vs | Gzira U. | 2-0 | Alexander Satariano, Arthur Henrique Oyama |
| 01-Feb | Santa Lucia | vs | Gudja U. | 2-1 | Kevin Ante Rosero Jackson Usuga Mendoza (SL); Rundell Winchester (G) |
| 01-Feb | Hamrun S. | vs | Tarxien R. | 2-3 | Andre Scicluna, Nicola Leone (H); Aleksa Andrejic (3)(T) |
| 01-Feb | Mosta | vs | Senglea A. | 1-0 | Rafael Morisco |
| 02-Feb | Floriana | vs | Valletta | 0-1 | Steve Borg |
| 02-Feb | Hibernians | vs | Sirens | 0-2 | Wellington de Oliveira, Ricardo Silva Faria |
| 03-Feb | Balzan | vs | Birkirkara | 0-0 | |
| 08-Feb | Gudja U. | vs | Sliema W. | 1-0 | Rundell Winchester |
| 08-Feb | Birkirkara | vs | Mosta | 2-1 | Isaac Ntow, Matthew Guillaumier (B); Christian Eric Chaney (M) |
| 08-Feb | Valletta | vs | Balzan | 3-1 | Mario Fontanella (3)(V); Ivan Bozovic (B) |
| 08-Feb | Gzira U. | vs | Floriana | 2-2 | Stefano D’Agostino, Tiago Adan Fonseca (F); Marco Criaco (2)(G) |
| 09-Feb | Tarxien R. | vs | Santa Lucia | 1-3 | Maxuell Maia da Silva (2), Paulo Henrique Santos de Azevedo (SL); Miguel Ciantar (T) |
| 09-Feb | Senglea A. | vs | Hibernians | 1-1 | Jake Grech, JOse Wilkson Teixeira (S) |
| 10-Feb | Sirens | vs | Hamrun S. | 1-2 | Wellinton de Oliveira (S); Clayton Failla, Nicolas Leone (H) |
| 15-Feb | Santa Lucia | vs | Sirens | 0-2 | Flavio Silva Cheveresan, Emmanuel Okoye |
| 15-Feb | Floriana | vs | Gudja U. | 1-2 | Matias Nicolas Garcia (F); own goal, Miguel Antonio Jimenez (G) |
| 15-Feb | Sliema W. | vs | Tarxien R. | 1-0 | Jean Paul Farrugia |
| 15-Feb | Hibernians | vs | Mosta | 3-1 | Gabriel Aquilina (M); Jake Grech, Joseph Mbong, Imanol Iriberri (H) |
| 16-Feb | Balzan | vs | Gzira U. | 1-3 | Rodolfo Soares, Hamed Kone, Amadou Samb (G); Alfred Effiong (B) |
| 16-Feb | Valletta | vs | Birkirkara | 1-4 | Miguel Angel Alba (V); Enrico Pepe, Paul Mbong, Federico Falcone, Oscar Matias Carniello (B) |
| 17-Feb | Hamrun S. | vs | Senglea A. | 1-0 | Soufiane Lagzir |
| 21-Feb | Tarxien R. | vs | Floriana | 0-4 | Tiago Adan Fonseca, Kristian Keqi, Diego Venancio, Matias Garcia |
| 21-Feb | Sirens | vs | Sliema W. | 0-0 | |
| 21-Feb | Gzira U. | vs | Valletta | 0-1 | Steve Borg |
| 22-Feb | Gudja U. | vs | Balzan | 0-2 | Ricardo Calixto Correa, Steve Pisani |
| 22-Feb | Senglea A. | vs | Santa Lucia | 2-5 | Kevin Pinheiro Correia, Rei Tachikawa (2), Maxuell Maia da Silva, Jacob Walker (SL); Juninho Cabral, Joe Wilkson Teixeira (SA) |
| 22-Feb | Mosta | vs | Hamrun S. | 2-1 | Weverton Gomes (2)(M); Soufiane Lagzir (H) |
| 22-Feb | Birkirkara | vs | Hibernians | 2-1 | own goal, Yannick Yankam (B); Jake Grech (H) |
| 06-Mar | Floriana | vs | Sirens | 3-0 | Kristian Keqi (3) |
| 07-Mar | Santa Lucia | vs | Mosta | 1-2 | Maxuell Maia da Silva (SL); Duane Bonnici, Takanori Yokochi (M) |
| 07-Mar | Valletta | vs | Gudja U. | 0-2 | Nivaldo Rodrigues Ferreira, Gabriel Mensah |
| 07-Mar | Sliema W. | vs | Senglea A. | 4-1 | Juninho Cabral (SA); Juan Cruz Gill, Juri Cisotti, Alexander Satariano, Michele Sansone (SW) |
| 07-Mar | Hamrun S. | vs | Hibernians | 1-2 | Myles Beerman, Jake Grech (Hib); Ailton Jorge dos Santos Soares (HS) |
| 08-Mar | Balzan | vs | Tarxien R. | 3-0 | Steve Pisani, Adeseyi Adeyoka, Ricardo Calixto Correa |
| 08-Mar | Gzira U. | vs | Birkirkara | 0-2 | Caio Henrique Prado Rocha, Diego Capel |
| Tarxien R. | vs | Valletta | Matches were initially postponed and later cancelled after a decision by the MFA Executive Committee to terminate the BOV Premier League on May 18 due to the COVID-19 pandemic. | ||
| Mosta | vs | Sliema W. | |||
| Hibernians | vs | Santa Lucia | |||
| Gudja U. | vs | Gzira U. | |||
| Sirens | vs | Balzan | |||
| Senglea A. | vs | Floriana | |||
| Birkirkara | vs | Hamrun S. | |||
| Santa Lucia | vs | Hamrun S. | |||
| Gudja U. | vs | Birkirkara | |||
| Balzan | vs | Senglea A. | |||
| Gzira U. | vs | Tarxien R. | |||
| Valletta | vs | Sirens | |||
| Sliema W. | vs | Hibernians | |||
| Floriana | vs | Mosta | |||
| Tarxien R. | vs | Gudja U. | |||
| Mosta | vs | Balzan | |||
| Birkirkara | vs | Santa Lucia | |||
| Hibernians | vs | Floriana | |||
| Senglea A. | vs | Valletta | |||
| Sirens | vs | Gzira U. | |||
| Hamrun S. | vs | Sliema W. | |||
| Gudja U. | vs | Sirens | |||
| Sliema W. | vs | Santa Lucia | |||
| Gzira U. | vs | Senglea A. | |||
| Floriana | vs | Hamrun S. | |||
| Tarxien R. | vs | Birkirkara | |||
| Balzan | vs | Hibernians | |||
| Valletta | vs | Mosta | |||
| Birkirkara | vs | Sliema W. | |||
| Sirens | vs | Tarxien R. | |||
| Senglea A. | vs | Gudja U. | |||
| Hamrun S. | vs | Balzan | |||
| Santa Lucia | vs | Floriana | |||
| Mosta | vs | Gzira U. | |||
| Hibernians | vs | Valletta | |||
| Sirens | vs | Birkirkara | |||
| Floriana | vs | Sliema W. | |||
| Tarxien R. | vs | Senglea A. | |||
| Balzan | vs | Santa Lucia | |||
| Gudja U. | vs | Mosta | |||
| Valletta | vs | Hamrun S. | |||
| Gzira U. | vs | Hibernians | |||