| Date | Home | vs | Away | Result | Scorers |
| 12-Sep | Xghajra T. | vs | Luqa SA | 3-1 | Royter Degiorgio, Nestor Luis Silva Canas (X); Gilbert Camilleri (L) |
| 12-Sep | Kalkara U. | vs | Marsaxlokk | 1-0 | Yessous Camilleri |
| 14-Sep | San Gwann | vs | Mgarr U. | 0-0 | |
| 14-Sep | Zurrieq | vs | Birzebbuga SP | 1-1 | Andrea Sant (B); Claudio Calleja (Z) |
| 15-Sep | Marsa | vs | Rabat A. | 2-2 | Paul Lapira, Christian Caruana (M); Immy Micallef, Javier Jimenez (R) |
| 15-Sep | Melita | vs | Mellieha | 0-0 | |
| 21-Sep | Mgarr U. | vs | Melita | 1-2 | Fabien Lufi, Andrew Sant (Mel); Matthew Agius (Mga) |
| 21-Sep | Mellieha | vs | Zurrieq | 1-4 | own goal, Andre Joe Cutajar, Ayrton Micallef, Mauro Bonnici (Z); Michael Micallef (M) |
| 23-Sep | Birzebbuga SP | vs | Kalkara U. | 1-3 | Emmanuel Mbong (2), Larson Mallia (K); Christopher Cutajar (B) |
| 23-Sep | Luqa SA | vs | Marsa | 3-3 | Dario Aquilina (2), Samba Camara (L); own goal, Erik Pietribiasi (2)(M) |
| 22-Sep | Rabat A. | vs | San Gwann | 1-1 | Luke Gatt (R); Adam Falzon (SG) |
| 22-Sep | Zabbar SP | vs | Xghajra T. | 0-0 | |
| 28-Sep | Kalkara U. | vs | Mellieha | 2-4 | Mark Saliba, Mattei Vella, Jordan Debattista, Michael Micallef (M); Timothy Thomas, Emmanuel Mbong (K) |
| 28-Sep | Marsaxlokk | vs | Zabbar SP | 1-0 | Alan Tabone |
| 29-Sep | Melita | vs | Rabat A. | 3-0 | Daniel Claridge (2), Julian Abela |
| 29-Sep | Xghajra T. | vs | Marsa | 1-4 | Shalon Diacono, Paul Lapira, Luca Gatt, Erik Pietribiasi (M); Royter Degiorgio (X) |
| 30-Sep | San Gwann | vs | Luqa SA | 2-0 | Luca Mallia, Owen Spiteri |
| 30-Sep | Zurrieq | vs | Mgarr U. | 0-2 | Lyden Micallef, Jack Vella |
| 05-Oct | Zabbar SP | vs | Birzebbuga SP | 0-0 | |
| 06-Oct | Rabat A. | vs | Zurrieq | 1-0 | Larens Vella |
| 06-Oct | Mgarr U. | vs | Kalkara U. | 4-1 | Kenneth Aquilina (2), Lazar Doric (2) (M); Timothy Thomas (K) |
| 05-Oct | Luqa SA | vs | Melita | 0-2 | Andrew Sant, Noel Omondi |
| 06-Oct | Marsaxlokk | vs | Xghajra T. | 2-1 | Denilson Borg Castaldi, Alan Tabone (M); Royter Degiorgio (X) |
| 06-Oct | Marsa | vs | San Gwann | 3-1 | Erik Pietribiasi, Nicholas Zammit, Shalon Diacono (M); Courage Omoruanzoje (SG) |
| 11-Oct | Kalkara U. | vs | Rabat A. | 0-2 | Neil Caruana, Brandon Micallef |
| 11-Oct | Mellieha | vs | Zabbar SP | 0-0 | |
| 13-Oct | Xghajra T. | vs | San Gwann | 2-2 | Adam Falzon, Christian Gauci (SG); Royter Degiorgio, Nestor Luis Silva Canas (X) |
| 13-Oct | Birzebbuga SP | vs | Marsaxlokk | 0-4 | Ryan Sell (2), Keith Muscat, Daniel Debono |
| 13-Oct | Melita | vs | Marsa | 1-0 | Shalon Diacono |
| 13-Oct | Zurrieq | vs | Luqa SA | 2-0 | Claudio Calleja, Warren Zerafa |
| 17-Oct | Zabbar SP | vs | Mgarr U. | 0-2 | Lyden Micallef, Kenneth Aquilina |
| 17-Oct | Birzebbuga SP | vs | Xghajra T. | 4-0 | Andrea Sant (3), Luke Zahra |
| 19-Oct | San Gwann | vs | Melita | 1-1 | Adam Falzon (SG); Jean Pierre Attard (M) |
| 19-Oct | Marsaxlokk | vs | Mellieha | 0-0 | |
| 21-Oct | Marsa | vs | Zurrieq | 1-0 | Erik Pietribiasi |
| 21-Oct | Luqa SA | vs | Kalkara U. | 2-1 | Gilbert Camilleri, Lydon Micallef (L); Larson Mallia (K) |
| 03-Nov | Mellieha | vs | Birzebbuga SP | 1-3 | Sam Kind, Jean Claude Cassar, Gary Caruana (B); David Fenech (M) |
| 04-Nov | Zurrieq | vs | San Gwann | 0-1 | Jake Bowman |
| 02-Nov | Rabat A. | vs | Zabbar SP | 1-1 | Carl Magro (Z); Aidan Azzopardi (R) |
| 02-Nov | Xghajra T. | vs | Melita | 0-2 | Noel Omondi, Liam Reno Gatt |
| 03-Nov | Mgarr U. | vs | Marsaxlokk | 0-2 | Anthony Chimezie Ewurum (2) |
| 03-Nov | Kalkara U. | vs | Marsa | 3-3 | Larson Mallia (2), Aaron Agius (K); Mark Gauci, Paul Lapira, Ryan Previ (M) |
| 10-Nov | Mellieha | vs | Xghajra T. | 0-4 | |
| 09-Nov | San Gwann | vs | Kalkara U. | 3-0 | Owen Spiteri, Adam Falzon, Christain Gauci |
| 09-Nov | Melita | vs | Zurrieq | 1-2 | Claudio Calleja (2) (Z); Michael Cachia (M) |
| 10-Nov | Birzebbuga SP | vs | Mgarr U. | 0-2 | Kenneth Aquilina, Mark Abela |
| 10-Nov | Marsaxlokk | vs | Rabat A. | 4-0 | own goal, Ryan Micallef (2) |
| 11-Nov | Zabbar SP | vs | Luqa SA | 1-0 | Aidan Agius Gilford |
| 16-Nov | Rabat A. | vs | Birzebbuga SP | 4-0 | Kurt Camilleri, Larens Vella (3) |
| 16-Nov | Xghajra T. | vs | Zurrieq | 2-3 | Nestor Luis Silva Canas (2)(X); own goal, Ivan Bojovic, Ryan Farrugia (Z) |
| 16-Nov | Kalkara U. | vs | Melita | 3-2 | Aaron Agius, Beppe Antignolo, Larson Mallia (K); Jean Pierre Attard, Daniel Claridge (M) |
| 16-Nov | Marsa | vs | Zabbar SP | 3-1 | Terence Scerri (3)(M); Jean Claude Cesare (Z) |
| 17-Nov | Luqa SA | vs | Marsaxlokk | 0-0 | |
| 17-Nov | Mgarr U. | vs | Mellieha | 2-0 | John Paul Grima, Jamie Lee Micallef |
| 23-Nov | Mellieha | vs | Rabat A. | 1-3 | Luke Gatt (2), Immy Micallef (R); Marko Mitic (M) |
| 23-Nov | Mgarr U. | vs | Xghajra T. | 2-1 | Aaron Sammut, Jack Vella (M); Royter Degiorgio (X) |
| 24-Nov | Marsaxlokk | vs | Marsa | 3-3 | own goal, Erik Pietribiasi , Terence Scerri (Mrs); Ryan Micallef (3) (Mxl) |
| 24-Nov | Birzebbuga SP | vs | Luqa SA | 4-2 | Andy Portelli, Alan Abdelrahman (L); Joshua Farrugia (2), Gary Caruana, Clive Fenech (B) |
| 24-Nov | Zabbar SP | vs | San Gwann | 0-1 | Luca Mallia |
| 24-Nov | Zurrieq | vs | Kalkara U. | 1-1 | Jason Camilleri (Z); Isaac Galea (K) |
| 06-Dec | Luqa SA | vs | Mellieha | 0-2 | Marko Mitic, own goal |
| 08-Dec | Melita | vs | Zabbar SP | 2-0 | Michael Cachia, Isaac Zammit |
| 07-Dec | Xghajra T. | vs | Kalkara U. | 0-2 | Mauro Hammett, own goal |
| 07-Dec | San Gwann | vs | Marsaxlokk | 3-1 | Ryan Micallef (M); Luca Mallia, Justin Zammit, Andrea Zammit (SG) |
| 08-Dec | Marsa | vs | Birzebbuga SP | 8-0 | Nicholas Zammit (2), Paul Lapira (3), Damon Grima, Erik Pietribiasi, Ryan Gafa |
| 08-Dec | Rabat A. | vs | Mgarr U. | 1-0 | Larens Vella |
| 14-Dec | Zabbar SP | vs | Zurrieq | 0-3 | Ryan Farrugia, Adruian Caruana, Ivan Bojovic |
| 14-Dec | Mellieha | vs | Marsa | 0-3 | Erik Pietribiasi (2), Christian Caruana |
| 15-Dec | Rabat A. | vs | Xghajra T. | 3-2 | Luke Gatt, Larens Vella, Aidan Azzopardi (R); Royter Degiorgio, Nestor Luis Silva Canas (X) |
| 15-Dec | Mgarr U. | vs | Luqa SA | 3-2 | Alan Abdel Rahman, Gilbert Camilleri (L); Kenneth Aquilina (2), own goal (M) |
| 15-Dec | Marsaxlokk | vs | Melita | 2-2 | Noel Omondi, Matthew Debattista (Mel); Ryan Sammut, Keith Muscat (Mxl) |
| 15-Dec | Birzebbuga SP | vs | San Gwann | 0-7 | Christian Gauci (2), Justin Zammit, Andrea Zammit (3), Matthew Xuereb |
| 10-Jan | Melita | vs | Birzebbuga SP | 1-2 | Matthew Debattista (M); Christopher Cutajar, Brendan Scerri (B) |
| 11-Jan | Zurrieq | vs | Marsaxlokk | 0-1 | Keith Muscat |
| 11-Jan | San Gwann | vs | Mellieha | 0-1 | David Fenech |
| 12-Jan | Marsa | vs | Mgarr U. | 1-3 | Jamie Lee Micallef (2), Kenneth Aquilina (Mga); Shalon Diacono (MMar) |
| 12-Jan | Kalkara U. | vs | Zabbar SP | 3-1 | Shawn Vella (Z); Isaac Galea, Larson Mallia, Vladimir Tosic (K) |
| 12-Jan | Luqa SA | vs | Rabat A. | 0-1 | Aidan Azzopardi |
| 18-Jan | Marsaxlokk | vs | Kalkara U. | 5-0 | Anthony Chimezie, Keith Muscat, Pablo Doffo (2), Ryan Micallef |
| 18-Jan | Luqa SA | vs | Xghajra T. | 0-0 | |
| 19-Jan | Birzebbuga SP | vs | Zurrieq | 0-0 | |
| 19-Jan | Mgarr U. | vs | San Gwann | 2-2 | Aaron Sammut (2)(M); Nezar Abouhaiza, Luca Mallia (SG) |
| 19-Jan | Rabat A. | vs | Marsa | 0-3 | Lydon Micallef (3) |
| 19-Jan | Mellieha | vs | Melita | 2-1 | Michael Micallef, David Fenech (Mellieha); Jake Engerer (Melita) |
| 31-Jan | San Gwann | vs | Rabat A. | 1-0 | Dale Mifsud |
| 01-Feb | Xghajra T. | vs | Zabbar SP | 0-1 | Aidan Agius Gilford |
| 01-Feb | Melita | vs | Mgarr U. | 0-0 | |
| 02-Feb | Marsa | vs | Luqa SA | 2-1 | Francesco Gusman, Kurt Zammit (M); Darrell Grech (L) |
| 02-Feb | Zurrieq | vs | Mellieha | 3-0 | Ayrton Micallef, Andre Joe Cutajar, Daniel Debono |
| 02-Feb | Kalkara U. | vs | Birzebbuga SP | 2-0 | Ion Alin Margarit, Yessous Camilleri |
| 08-Feb | Mellieha | vs | Kalkara U. | 1-0 | David Fenech |
| 08-Feb | Mgarr U. | vs | Zurrieq | 1-2 | Claudio Calleja, Mauro Bonnici (Z); Gordon Saliba (M) |
| 09-Feb | Rabat A. | vs | Melita | 2-1 | Larens Vella, Nicolai Attard (R); Karl Mohnani (M) |
| 09-Feb | Luqa SA | vs | San Gwann | 1-2 | Andrea Zammit (2)(SG); own goal (L) |
| 09-Feb | Marsa | vs | Xghajra T. | 2-1 | Paul Lapira, Larson Mallia (M); Royter Degiorgio (X) |
| 09-Feb | Zabbar SP | vs | Marsaxlokk | 1-4 | Josef Dalli, Kenneth Aquilina, Ryan Micallef (2) (M); Aud-Gustine James Obaje (Z) |
| 15-Feb | San Gwann | vs | Marsa | 3-0 | Andrea Zammit (2), Joa Pedro Vargas |
| 15-Feb | Zurrieq | vs | Rabat A. | 0-0 | |
| 16-Feb | Kalkara U. | vs | Mgarr U. | 1-2 | Clayton Borg, Jamie Lee Micallef (M); Aaron Agius (K) |
| 16-Feb | Birzebbuga SP | vs | Zabbar SP | 0-2 | Shawn Vella (2) |
| 16-Feb | Melita | vs | Luqa SA | 2-0 | Luke Mifsud, Michael Cachia |
| 17-Feb | Xghajra T. | vs | Marsaxlokk | 0-4 | Kenneth Aquilina (2), Anthony Ewurum (2) |
| 22-Feb | Marsa | vs | Melita | 1-2 | Daniel Claridge, Luke Mifsud (Mel): Karl Conti (Mar) |
| 22-Feb | Luqa SA | vs | Zurrieq | 0-4 | Stefi Cale, Nicholas Zammit, Andre Joe Cutajar, Claudio Calleja |
| 23-Feb | Rabat A. | vs | Kalkara U. | 6-4 | Liam Reno Gatt (2), Aaron Agius, Randall Refalo (K); Kurt Muscat (2), Nicolai Attard, Chris Vella (3)(R) |
| 23-Feb | San Gwann | vs | Xghajra T. | 0-3 | Royter Degiorgio (2), Michael Scicluna |
| 23-Feb | Zabbar SP | vs | Mellieha | 2-0 | Aud-Gustine James Obaje, Shawn Vella |
| 24-Feb | Marsaxlokk | vs | Birzebbuga SP | 4-0 | Pablo Doffo, Keith Muscat, Ryan Micallef (2) |
| 29-Feb | Melita | vs | San Gwann | 0-3 | Andrea Zammit, Nezar Abouhaisa, Zack Bowman |
| 29-Feb | Mgarr U. | vs | Zabbar SP | 1-1 | own goal (M); Aud-Gustin James Obaje (Z) |
| 01-Mar | Kalkara U. | vs | Luqa SA | 0-1 | Lydon Sciberras |
| 01-Mar | Mellieha | vs | Marsaxlokk | 1-3 | Kenneth Aquilina, Ryan Micallef, Ivan Edgardo Paz (Mxl); Michael Micallef (Mel) |
| 01-Mar | Xghajra T. | vs | Birzebbuga SP | 1-1 | Lucka Covic (B); Miguel Scicluna (X) |
| 28-Feb | Zurrieq | vs | Marsa | 1-3 | Paul Lapira (2), Larson Mallia (M); Claudio Calleja (Z) |
| 07-Mar | Zabbar SP | vs | Rabat A. | 2-0 | Aud-Gustina James Obaje, Aidan Agius Gilford |
| 07-Mar | San Gwann | vs | Zurrieq | 2-0 | Joao Pedro Vargas, Jake Bowman |
| 08-Mar | Marsa | vs | Kalkara U. | 6-1 | Lydon Micallef (4), Paul Lapira, Larson Mallia (M); Beppe Antignolo (K) |
| 08-Mar | Melita | vs | Xghajra T. | 5-1 | Mark Russo (2), Daniel Claridge, Jake Engerer, Antoine Attard (M); Royter Degiorgio (X) |
| 08-Mar | Marsaxlokk | vs | Mgarr U. | 2-2 | Jamie Micallef, Lazar Doric (Mga); Josuel Spiteri, Christian Degabriele (Mxl) |
| 08-Mar | Birzebbuga SP | vs | Mellieha | 1-2 | Yaron Sammut, Jordan Debattista (M); Christopher Cutajar (B) |
| Mgarr U. | vs | Birzebbuga SP | Matches were initially postponed and later cancelled after a decision by the MFA Executive Committee to end all competitions on April 29 due to the COVID-19 pandemic. | ||
| Zurrieq | vs | Melita | |||
| Xghajra T. | vs | Mellieha | |||
| Rabat A. | vs | Marsaxlokk | |||
| Luqa SA | vs | Zabbar SP | |||
| Kalkara U. | vs | San Gwann | |||
| Melita | vs | Kalkara U. | |||
| Marsaxlokk | vs | Luqa SA | |||
| Zabbar SP | vs | Marsa | |||
| Birzebbuga SP | vs | Rabat A. | |||
| Zurrieq | vs | Xghajra T. | |||
| Mellieha | vs | Mgarr U. | |||
| Luqa SA | vs | Birzebbuga SP | |||
| Xghajra T. | vs | Mgarr U. | |||
| San Gwann | vs | Zabbar SP | |||
| Rabat A. | vs | Mellieha | |||
| Marsa | vs | Marsaxlokk | |||
| Kalkara U. | vs | Zurrieq | |||
| Kalkara U. | vs | Xghajra T. | |||
| Mgarr U. | vs | Rabat A. | |||
| Mellieha | vs | Luqa SA | |||
| Birzebbuga SP | vs | Marsa | |||
| Marsaxlokk | vs | San Gwann | |||
| Zabbar SP | vs | Melita | |||
| San Gwann | vs | Birzebbuga SP | |||
| Melita | vs | Marsaxlokk | |||
| Marsa | vs | Mellieha | |||
| Zurrieq | vs | Zabbar SP | |||
| Luqa SA | vs | Mgarr U. | |||
| Xghajra T. | vs | Rabat A. | |||
| Zabbar SP | vs | Kalkara U. | |||
| Marsaxlokk | vs | Zurrieq | |||
| Birzebbuga SP | vs | Melita | |||
| Mellieha | vs | San Gwann | |||
| Mgarr U. | vs | Marsa | |||
| Rabat A. | vs | Luqa SA | |||