| R | Date | Home | Score | Away | Location | |
| Round 1 | ||||||
| 10/09/2005 | Marsa | 2 - 0 | Mqabba | V. Tedesco Stadium | ||
| 10/09/2005 | San Gwann | 1 - 2 | St. Georges | V. Tedesco Stadium | ||
| 11/09/2005 | Naxxar L. | 1 - 2 | Tarxien R. | V. Tedesco Stadium | ||
| 11/09/2005 | St. Andrews | 0 - 1 | Senglea A. | V. Tedesco Stadium | ||
| 17/09/2005 | Lija A. | 2 - 2 | St. Patrick | V. Tedesco Stadium | ||
| Round 2 | ||||||
| 17/09/2005 | Senglea A. | 2 - 3 | Naxxar L. | V. Tedesco Stadium | ||
| 18/09/2005 | Tarxien R. | 2 - 3 | Marsa | V. Tedesco Stadium | ||
| 18/09/2005 | St. Georges | 1 - 0 | St. Andrews | V. Tedesco Stadium | ||
| 21/09/2005 | Mqabba | 3 - 1 | Lija A. | V. Tedesco Stadium | ||
| 21/09/2005 | St. Patrick | 0 - 1 | San Gwann | V. Tedesco Stadium | ||
| Round 3 | ||||||
| 24/09/2005 | Naxxar L. | 0 - 4 | Marsa | V. Tedesco Stadium | ||
| 24/09/2005 | Senglea A. | 0 - 2 | St. Georges | V. Tedesco Stadium | ||
| 25/09/2005 | Lija A. | 1 - 2 | Tarxien R. | V. Tedesco Stadium | ||
| 25/09/2005 | San Gwann | 1 - 1 | Mqabba | V. Tedesco Stadium | ||
| 01/10/2005 | St. Andrews | 1 - 1 | St. Patrick | V. Tedesco Stadium | ||
| Round 4 | ||||||
| 01/10/2005 | Marsa | 0 - 0 | Lija A. | V. Tedesco Stadium | ||
| 02/10/2005 | St. Georges | 3 - 1 | Naxxar L. | V. Tedesco Stadium | ||
| 02/10/2005 | Tarxien R. | 3 - 1 | San Gwann | V. Tedesco Stadium | ||
| 14/10/2005 | St. Patrick | 1 - 1 | Senglea A. | Centenary Stadium | ||
| 14/10/2005 | Mqabba | 2 - 0 | St. Andrews | Centenary Stadium | ||
| Round 5 | ||||||
| 17/10/2005 | Naxxar L. | 0 - 1 | Lija A. | Centenary Stadium | ||
| 17/10/2005 | San Gwann | 1 - 3 | Marsa | Centenary Stadium | ||
| 29/10/2005 | St. Georges | 2 - 0 | St. Patrick | Centenary Stadium | ||
| 29/10/2005 | St. Andrews | 2 - 2 | Tarxien R. | Centenary Stadium | ||
| 30/10/2005 | Senglea A. | 2 - 1 | Mqabba | Centenary Stadium | ||
| Round 6 | ||||||
| 30/10/2005 | Lija A. | 0 - 2 | San Gwann | Centenary Stadium | ||
| 19/11/2005 | St. Patrick | 4 - 1 | Naxxar L. | Centenary Stadium | ||
| 19/11/2005 | Marsa | 1 - 1 | St. Andrews | Centenary Stadium | ||
| 20/11/2005 | Mqabba | 0 - 0 | St. Georges | Centenary Stadium | ||
| 20/11/2005 | Tarxien R. | 1 - 0 | Senglea A. | Centenary Stadium | ||
| Round 7 | ||||||
| 30/11/2005 | Naxxar L. | 4 - 0 | San Gwann | Centenary Stadium | ||
| 30/11/2005 | St. Andrews | 3 - 2 | Lija A. | Centenary Stadium | ||
| 04/12/2005 | St. Patrick | 1 - 2 | Mqabba | V. Tedesco Stadium | ||
| 04/12/2005 | Senglea A. | 0 - 0 | Marsa | V. Tedesco Stadium | ||
| 16/12/2005 | St. Georges | 1 - 0 | Tarxien R. | Centenary Stadium | ||
| Round 8 | ||||||
| 16/12/2005 | San Gwann | 3 - 0 | St. Andrews | Centenary Stadium | ||
| 18/12/2005 | Mqabba | 4 - 1 | Naxxar L. | V. Tedesco Stadium | ||
| 18/12/2005 | Lija A. | 2 - 1 | Senglea A. | V. Tedesco Stadium | ||
| 08/01/2006 | Tarxien R. | 1 - 1 | St. Patrick | V. Tedesco Stadium | ||
| 08/01/2006 | Marsa | 1 - 0 | St. Georges | V. Tedesco Stadium | ||
| Round 9 | ||||||
| 18/01/2006 | Naxxar L. | 3 - 0 | St. Andrews | Centenary Stadium | ||
| 18/01/2006 | Senglea A. | 2 - 1 | San Gwann | Centenary Stadium | ||
| 25/01/2006 | Mqabba | 0 - 2 | Tarxien R. | Centenary Stadium | ||
| 25/01/2006 | St. Georges | 1 - 2 | Lija A. | Centenary Stadium | ||
| 29/01/2006 | St. Patrick | 2 - 1 | Marsa | Hibs Ground | ||
| Round 10 | ||||||
| 29/01/2006 | Tarxien R. | 0 - 0 | Naxxar L. | Hibs Ground | ||
| 05/02/2006 | Senglea A. | 3 - 1 | St. Andrews | V. Tedesco Stadium | ||
| 05/02/2006 | Mqabba | 4 - 0 | Marsa | V. Tedesco Stadium | ||
| 11/02/2006 | St. Patrick | 2 - 1 | Lija A. | V. Tedesco Stadium | ||
| 11/02/2006 | St. Georges | 1 - 0 | San Gwann | V. Tedesco Stadium | ||
| Round 11 | ||||||
| 26/02/2006 | Naxxar L. | 3 - 2 | Senglea A. | V. Tedesco Stadium | ||
| 26/02/2006 | Marsa | 0 - 2 | Tarxien R. | V. Tedesco Stadium | ||
| 05/03/2006 | Lija A. | 1 - 1 | Mqabba | V. Tedesco Stadium | ||
| 05/03/2006 | St. Andrews | 0 - 3 | St. Georges | V. Tedesco Stadium | ||
| 12/03/2006 | San Gwann | 0 - 3 | St. Patrick | V. Tedesco Stadium | ||
| Round 12 | ||||||
| 12/03/2006 | Marsa | 4 - 2 | Naxxar L. | V. Tedesco Stadium | ||
| 19/03/2006 | Tarxien R. | 2 - 0 | Lija A. | V. Tedesco Stadium | ||
| 19/03/2006 | St. Georges | 2 - 2 | Senglea A. | V. Tedesco Stadium | ||
| 25/03/2006 | Mqabba | 1 - 0 | San Gwann | Hibs Ground | ||
| 25/03/2006 | St. Patrick | 5 - 1 | St. Andrews | Hibs Ground | ||
| Round 13 | ||||||
| 26/03/2006 | Lija A. | 0 - 3 | Marsa | V. Tedesco Stadium | ||
| 26/03/2006 | Naxxar L. | 1 - 1 | St. Georges | V. Tedesco Stadium | ||
| 01/04/2006 | San Gwann | 2 - 1 | Tarxien R. | Hibs Ground | ||
| 01/04/2006 | Senglea A. | 1 - 0 | St. Patrick | Hibs Ground | ||
| 02/04/2006 | St. Andrews | 0 - 1 | Mqabba | V. Tedesco Stadium | ||
| Round 14 | ||||||
| 02/04/2006 | Lija A. | 0 - 4 | Naxxar L. | V. Tedesco Stadium | ||
| 08/04/2006 | Marsa | 2 - 2 | San Gwann | Hibs Ground | ||
| 08/04/2006 | St. Patrick | 0 - 1 | St. Georges | Hibs Ground | ||
| 09/04/2006 | Tarxien R. | 1 - 1 | St. Andrews | V. Tedesco Stadium | ||
| 09/04/2006 | Mqabba | 1 - 2 | Senglea A. | V. Tedesco Stadium | ||
| Round 15 | ||||||
| 15/04/2006 | St. Georges | 1 - 1 | Mqabba | V. Tedesco Stadium | ||
| 15/04/2006 | San Gwann | 2 - 0 | Lija A. | V. Tedesco Stadium | ||
| 16/04/2006 | St. Andrews | 1 - 1 | Marsa | V. Tedesco Stadium | ||
| 16/04/2006 | Naxxar L. | 1 - 2 | St. Patrick | V. Tedesco Stadium | ||
| 22/04/2006 | Senglea A. | 1 - 0 | Tarxien R. | Hibs Ground | ||
| Round 16 | ||||||
| 22/04/2006 | San Gwann | 4 - 1 | Naxxar L. | Hibs Ground | ||
| 23/04/2006 | Lija A. | 4 - 2 | St. Andrews | V. Tedesco Stadium | ||
| 23/04/2006 | Mqabba | 0 - 2 | St. Patrick | V. Tedesco Stadium | ||
| 29/04/2006 | Marsa | 3 - 0 | Senglea A. | Hibs Ground | ||
| 29/04/2006 | Tarxien R. | 2 - 1 | St. Georges | Hibs Ground | ||
| Round 17 | ||||||
| 30/04/2006 | St. Andrews | 0 - 2 | San Gwann | V. Tedesco Stadium | ||
| 30/04/2006 | Naxxar L. | 2 - 5 | Mqabba | V. Tedesco Stadium | ||
| 06/05/2006 | Senglea A. | 0 - 2 | Lija A. | Hibs Ground | ||
| 06/05/2006 | St. Patrick | 2 - 2 | Tarxien R. | Hibs Ground | ||
| 07/05/2006 | St. Georges | 2 - 2 | Marsa | V. Tedesco Stadium | ||
| Round 18 | ||||||
| 07/05/2006 | St. Andrews | 0 - 4 | Naxxar L. | V. Tedesco Stadium | ||
| 13/05/2006 | San Gwann | 0 - 1 | Senglea A. | Hibs Ground | ||
| 13/05/2006 | Tarxien R. | 0 - 1 | Mqabba | Hibs Ground | ||
| 14/05/2006 | Lija A. | 1 - 3 | St. Georges | V. Tedesco Stadium | ||
| 14/05/2006 | Marsa | 3 - 1 | St. Patrick | V. Tedesco Stadium |
| Created on 14/05/2006 with LeaguePad |
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