| R | Date | Home | Score | Away | Location | |
| 1 | 23/09/2007 | San Gwann | 1 - 1 | Sirens | Centenary Stadium | |
| 2 | 06/10/2007 | Sirens | 0 - 2 | Lija A. | Centenary Stadium | |
| 3 | 13/10/2007 | St. Andrews | 1 - 1 | Sirens | Centenary Stadium | |
| 4 | 21/10/2007 | Sirens | 1 - 3 | Melita | Centenary Stadium | |
| 5 | 02/11/2007 | Sirens | 0 - 1 | Rabat A. | Centenary Stadium | |
| 7 | 25/11/2007 | Sirens | 0 - 0 | Mgarr U. | Centenary Stadium | |
| 8 | 09/12/2007 | Sta. Venera L. | 2 - 1 | Sirens | Centenary Stadium | |
| 9 | 16/12/2007 | Sirens | 0 - 1 | Birzebbuga SP | Centenary Stadium | |
| 10 | 04/01/2008 | Naxxar L. | 1 - 0 | Sirens | Centenary Stadium | |
| 6 | 08/01/2008 | Balzan Y. | 4 - 0 | Sirens | Centenary Stadium | |
| 11 | 13/01/2008 | Sirens | 0 - 1 | Zurrieq | Centenary Stadium | |
| 12 | 20/01/2008 | Sirens | 1 - 4 | San Gwann | Centenary Stadium | |
| 13 | 03/02/2008 | Lija A. | 4 - 0 | Sirens | Centenary Stadium | |
| 14 | 10/02/2008 | Sirens | 1 - 2 | St. Andrews | Centenary Stadium | |
| 15 | 22/02/2008 | Melita | 5 - 0 | Sirens | Centenary Stadium | |
| 16 | 02/03/2008 | Rabat A. | 3 - 0 | Sirens | Centenary Stadium | |
| 17 | 16/03/2008 | Sirens | 1 - 5 | Balzan Y. | Centenary Stadium | |
| 18 | 30/03/2008 | Mgarr U. | 3 - 0 | Sirens | Centenary Stadium | |
| 19 | 12/04/2008 | Sirens | 2 - 1 | Sta. Venera L. | Centenary Stadium | |
| 20 | 20/04/2008 | Birzebbuga SP | 2 - 1 | Sirens | Centenary Stadium | |
| 21 | 01/05/2008 | Sirens | 0 - 5 | Naxxar L. | Centenary Stadium | |
| 22 | 11/05/2008 | Zurrieq | 4 - 1 | Sirens | Centenary Stadium |
| Created on 11/05/2008 with LeaguePad |
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| Birzebbuga SP Matches |
| Lija A. Matches |
| Melita Matches |
| Mgarr U. Matches |
| Naxxar L. Matches |
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| St. Andrews Matches |
| Sta. Venera L. Matches |
| Zurrieq Matches |