| Matches by round |
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| Match list: | By round By date Latest | Player stats: |
| R | Date | Home | Score | Away | Location | |
| 1 | 26/09/2010 | Santa Lucia | 0 - 2 | Gudja U. | Centenary Stadium | |
| 2 | 04/10/2010 | Sta. Venera L. | 2 - 0 | Santa Lucia | Centenary Stadium | |
| 3 | 14/10/2010 | Santa Lucia | 0 - 3 | Siggiewi | Centenary Stadium | |
| 4 | 22/10/2010 | Qrendi | 1 - 2 | Santa Lucia | Centenary Stadium | |
| 5 | 01/11/2010 | Santa Lucia | 3 - 0 | Mdina K. | Centenary Stadium | |
| 6 | 08/11/2010 | Attard | 1 - 2 | Santa Lucia | Centenary Stadium | |
| 7 | 22/11/2010 | Santa Lucia | 0 - 0 | Xghajra T. | Centenary Stadium | |
| 8 | 04/12/2010 | Marsaskala | 2 - 3 | Santa Lucia | Centenary Stadium | |
| 9 | 12/12/2010 | Santa Lucia | 2 - 0 | Swieqi U. | Centenary Stadium | |
| 10 | 19/12/2010 | Mtarfa | 1 - 1 | Santa Lucia | Centenary Stadium | |
| 12 | 14/01/2011 | Gudja U. | 1 - 2 | Santa Lucia | Centenary Stadium | |
| 13 | 28/01/2011 | Santa Lucia | 0 - 3 | Sta. Venera L. | Centenary Stadium | |
| 14 | 06/02/2011 | Siggiewi | 3 - 0 | Santa Lucia | Centenary Stadium | |
| 15 | 13/02/2011 | Santa Lucia | 1 - 0 | Qrendi | Centenary Stadium | |
| 16 | 03/03/2011 | Mdina K. | 1 - 0 | Santa Lucia | Centenary Stadium | |
| 17 | 11/03/2011 | Santa Lucia | 0 - 4 | Attard | Centenary Stadium | |
| 18 | 20/03/2011 | Xghajra T. | 2 - 0 | Santa Lucia | Centenary Stadium | |
| 19 | 28/03/2011 | Santa Lucia | 0 - 3 | Marsaskala | Centenary Stadium | |
| 20 | 08/04/2011 | Swieqi U. | 1 - 0 | Santa Lucia | Centenary Stadium | |
| 21 | 23/04/2011 | Santa Lucia | 0 - 0 | Mtarfa | Centenary Stadium |