| R | Date | Home | Score | Away | Location | |
| 1 | 25/09/2005 | Ghaxaq | 0 - 1 | Sta. Lucia | Centenary Stadium | |
| 2 | 08/10/2005 | Mgarr U. | 1 - 0 | Ghaxaq | Centenary Stadium | |
| 3 | 21/10/2005 | Ghaxaq | 0 - 2 | Rabat A. | Centenary Stadium | |
| 4 | 30/10/2005 | Fgura U. | 2 - 0 | Ghaxaq | Centenary Stadium | |
| 5 | 20/11/2005 | Birzebbuga SP | 4 - 0 | Ghaxaq | Centenary Stadium | |
| 6 | 03/12/2005 | Ghaxaq | 3 - 2 | Xghajra T. | Centenary Stadium | |
| 7 | 18/12/2005 | Ta Xbiex | 1 - 4 | Ghaxaq | Centenary Stadium | |
| 8 | 13/01/2006 | Ghaxaq | 2 - 1 | Siggiewi | Centenary Stadium | |
| 9 | 29/01/2006 | Kirkop U. | 1 - 1 | Ghaxaq | Centenary Stadium | |
| 10 | 11/02/2006 | Ghaxaq | 0 - 1 | Sirens | Centenary Stadium | |
| 12 | 28/02/2006 | Kalkara | 1 - 0 | Ghaxaq | Centenary Stadium | |
| 13 | 12/03/2006 | Ghaxaq | 1 - 0 | Zejtun C. | Centenary Stadium | |
| 14 | 27/03/2006 | Luqa SA | 1 - 1 | Ghaxaq | Centenary Stadium | |
| 15 | 08/04/2006 | Ghaxaq | 1 - 1 | Zurrieq | Centenary Stadium | |
| 16 | 27/04/2006 | Sta. Venera L. | 4 - 1 | Ghaxaq | Centenary Stadium | |
| 17 | 05/05/2006 | Ghaxaq | 1 - 5 | Pembroke A. | Centenary Stadium |
| Created on 07/05/2006 with LeaguePad |
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| Sta. Lucia Matches |
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| Zejtun C. Matches |
| Zurrieq Matches |