| Matches by round |
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| Match list: | By round By date Latest | Player stats: |
| R | Date | Home | Score | Away | Location | |
| Round 1 | ||||||
| 26/09/2010 | Naxxar L. | 0 - 1 | Zejtun C. | Centenary Stadium | ||
| 26/09/2010 | Zurrieq | 2 - 3 | Mellieha | Centenary Stadium | ||
| 28/09/2010 | Mgarr U. | 0 - 1 | Zebbug R. | Centenary Stadium | ||
| 28/09/2010 | Birzebbuga SP | 0 - 0 | Gzira U. | Centenary Stadium | ||
| 02/10/2010 | San Gwann | 1 - 2 | St. Patrick | Centenary Stadium | ||
| 02/10/2010 | Rabat A. | 4 - 0 | Senglea A. | Centenary Stadium | ||
| Round 2 | ||||||
| 03/10/2010 | Zejtun C. | 3 - 1 | Mgarr U. | Centenary Stadium | ||
| 03/10/2010 | Mellieha | 0 - 1 | Naxxar L. | Centenary Stadium | ||
| 09/10/2010 | Gzira U. | 2 - 2 | Zurrieq | Centenary Stadium | ||
| 09/10/2010 | Zebbug R. | 1 - 0 | San Gwann | Centenary Stadium | ||
| 10/10/2010 | Senglea A. | 4 - 0 | Birzebbuga SP | Centenary Stadium | ||
| 10/10/2010 | St. Patrick | 0 - 4 | Rabat A. | Centenary Stadium | ||
| Round 3 | ||||||
| 15/10/2010 | Naxxar L. | 3 - 2 | Mgarr U. | Centenary Stadium | ||
| 15/10/2010 | Mellieha | 2 - 0 | Gzira U. | Centenary Stadium | ||
| 16/10/2010 | San Gwann | 1 - 1 | Zejtun C. | Centenary Stadium | ||
| 16/10/2010 | Zurrieq | 0 - 2 | Senglea A. | Centenary Stadium | ||
| 17/10/2010 | Rabat A. | 2 - 0 | Zebbug R. | Centenary Stadium | ||
| 17/10/2010 | Birzebbuga SP | 1 - 0 | St. Patrick | Centenary Stadium | ||
| Round 4 | ||||||
| 23/10/2010 | Mgarr U. | 1 - 4 | San Gwann | Centenary Stadium | ||
| 23/10/2010 | Gzira U. | 3 - 2 | Naxxar L. | Centenary Stadium | ||
| 24/10/2010 | Senglea A. | 0 - 1 | Mellieha | Centenary Stadium | ||
| 24/10/2010 | Zejtun C. | 1 - 0 | Rabat A. | Centenary Stadium | ||
| 30/10/2010 | St. Patrick | 2 - 0 | Zurrieq | Centenary Stadium | ||
| 30/10/2010 | Zebbug R. | 0 - 3 | Birzebbuga SP | Centenary Stadium | ||
| Round 5 | ||||||
| 31/10/2010 | Gzira U. | 2 - 2 | Senglea A. | Centenary Stadium | ||
| 31/10/2010 | Naxxar L. | 4 - 0 | San Gwann | Centenary Stadium | ||
| 06/11/2010 | Mellieha | 3 - 1 | St. Patrick | Centenary Stadium | ||
| 06/11/2010 | Rabat A. | 0 - 1 | Mgarr U. | Centenary Stadium | ||
| 07/11/2010 | Zurrieq | 0 - 3 | Zebbug R. | Centenary Stadium | ||
| 07/11/2010 | Birzebbuga SP | 0 - 1 | Zejtun C. | Centenary Stadium | ||
| Round 6 | ||||||
| 13/11/2010 | Senglea A. | 2 - 3 | Naxxar L. | Centenary Stadium | ||
| 13/11/2010 | San Gwann | 1 - 4 | Rabat A. | Centenary Stadium | ||
| 14/11/2010 | Mgarr U. | 1 - 2 | Birzebbuga SP | Centenary Stadium | ||
| 14/11/2010 | St. Patrick | 1 - 1 | Gzira U. | Centenary Stadium | ||
| 20/11/2010 | Zejtun C. | 0 - 2 | Zurrieq | Centenary Stadium | ||
| 20/11/2010 | Zebbug R. | 0 - 1 | Mellieha | Centenary Stadium | ||
| Round 7 | ||||||
| 21/11/2010 | Senglea A. | 7 - 1 | St. Patrick | Centenary Stadium | ||
| 21/11/2010 | Naxxar L. | 0 - 1 | Rabat A. | Centenary Stadium | ||
| 27/11/2010 | Gzira U. | 2 - 2 | Zebbug R. | Centenary Stadium | ||
| 27/11/2010 | Birzebbuga SP | 3 - 0 | San Gwann | Centenary Stadium | ||
| 28/11/2010 | Mellieha | 0 - 1 | Zejtun C. | Centenary Stadium | ||
| 28/11/2010 | Zurrieq | 0 - 0 | Mgarr U. | Centenary Stadium | ||
| Round 8 | ||||||
| 03/12/2010 | Rabat A. | 1 - 1 | Birzebbuga SP | Centenary Stadium | ||
| 03/12/2010 | Mgarr U. | 1 - 2 | Mellieha | Centenary Stadium | ||
| 12/12/2010 | St. Patrick | 3 - 0 | Naxxar L. | Centenary Stadium | ||
| 12/12/2010 | Zebbug R. | 2 - 1 | Senglea A. | Centenary Stadium | ||
| 13/12/2010 | San Gwann | 1 - 1 | Zurrieq | Centenary Stadium | ||
| 13/12/2010 | Zejtun C. | 0 - 1 | Gzira U. | Centenary Stadium | ||
| Round 9 | ||||||
| 18/12/2010 | St. Patrick | 3 - 0 | Zebbug R. | Centenary Stadium | ||
| 18/12/2010 | Naxxar L. | 4 - 1 | Birzebbuga SP | Centenary Stadium | ||
| 19/12/2010 | Senglea A. | 1 - 2 | Zejtun C. | Centenary Stadium | ||
| 19/12/2010 | Zurrieq | 0 - 4 | Rabat A. | Centenary Stadium | ||
| 20/12/2010 | Gzira U. | 4 - 0 | Mgarr U. | Centenary Stadium | ||
| 20/12/2010 | Mellieha | 4 - 0 | San Gwann | Centenary Stadium | ||
| Round 10 | ||||||
| 02/01/2011 | Zebbug R. | 2 - 3 | Naxxar L. | Centenary Stadium | ||
| 02/01/2011 | Birzebbuga SP | 6 - 1 | Zurrieq | Centenary Stadium | ||
| 03/01/2011 | Rabat A. | 0 - 1 | Mellieha | Centenary Stadium | ||
| 03/01/2011 | Zejtun C. | 4 - 0 | St. Patrick | Centenary Stadium | ||
| 08/01/2011 | San Gwann | 2 - 1 | Gzira U. | Centenary Stadium | ||
| 08/01/2011 | Mgarr U. | 1 - 5 | Senglea A. | Centenary Stadium | ||
| Round 11 | ||||||
| 09/01/2011 | Zebbug R. | 0 - 3 | Zejtun C. | Centenary Stadium | ||
| 09/01/2011 | Naxxar L. | 3 - 2 | Zurrieq | Centenary Stadium | ||
| 15/01/2011 | St. Patrick | 2 - 0 | Mgarr U. | Centenary Stadium | ||
| 15/01/2011 | Mellieha | 0 - 0 | Birzebbuga SP | Centenary Stadium | ||
| 16/01/2011 | Senglea A. | 0 - 2 | San Gwann | Centenary Stadium | ||
| 16/01/2011 | Gzira U. | 1 - 5 | Rabat A. | Centenary Stadium | ||
| Round 12 | ||||||
| 22/01/2011 | Mellieha | 1 - 2 | Zurrieq | Centenary Stadium | ||
| 22/01/2011 | Zejtun C. | 0 - 0 | Naxxar L. | Centenary Stadium | ||
| 23/01/2011 | Gzira U. | 2 - 3 | Birzebbuga SP | Centenary Stadium | ||
| 23/01/2011 | Zebbug R. | 4 - 0 | Mgarr U. | Centenary Stadium | ||
| 24/01/2011 | Senglea A. | 1 - 0 | Rabat A. | Centenary Stadium | ||
| 24/01/2011 | St. Patrick | 3 - 1 | San Gwann | Centenary Stadium | ||
| Round 13 | ||||||
| 29/01/2011 | Naxxar L. | 2 - 0 | Mellieha | Centenary Stadium | ||
| 29/01/2011 | Mgarr U. | 0 - 1 | Zejtun C. | Centenary Stadium | ||
| 30/01/2011 | San Gwann | 1 - 1 | Zebbug R. | Centenary Stadium | ||
| 30/01/2011 | Zurrieq | 0 - 3 | Gzira U. | Centenary Stadium | ||
| 31/01/2011 | Rabat A. | 0 - 0 | St. Patrick | Centenary Stadium | ||
| 31/01/2011 | Birzebbuga SP | 2 - 0 | Senglea A. | Centenary Stadium | ||
| Round 14 | ||||||
| 05/02/2011 | Gzira U. | 1 - 2 | Mellieha | Centenary Stadium | ||
| 05/02/2011 | Mgarr U. | 2 - 1 | Naxxar L. | Centenary Stadium | ||
| 06/02/2011 | Senglea A. | 0 - 4 | Zurrieq | Centenary Stadium | ||
| 06/02/2011 | Zejtun C. | 3 - 0 | San Gwann | Centenary Stadium | ||
| 10/02/2011 | St. Patrick | 2 - 0 | Birzebbuga SP | Centenary Stadium | ||
| 10/02/2011 | Zebbug R. | 1 - 7 | Rabat A. | Centenary Stadium | ||
| Round 15 | ||||||
| 13/02/2011 | Naxxar L. | 3 - 0 | Gzira U. | Centenary Stadium | ||
| 13/02/2011 | San Gwann | 2 - 1 | Mgarr U. | Centenary Stadium | ||
| 19/02/2011 | Rabat A. | 0 - 0 | Zejtun C. | Centenary Stadium | ||
| 19/02/2011 | Mellieha | 2 - 2 | Senglea A. | Centenary Stadium | ||
| 20/02/2011 | Birzebbuga SP | 2 - 1 | Zebbug R. | Centenary Stadium | ||
| 20/02/2011 | Zurrieq | 2 - 0 | St. Patrick | Centenary Stadium | ||
| Round 16 | ||||||
| 26/02/2011 | San Gwann | 0 - 0 | Naxxar L. | Centenary Stadium | ||
| 26/02/2011 | Senglea A. | 2 - 2 | Gzira U. | Centenary Stadium | ||
| 27/02/2011 | Mgarr U. | 0 - 1 | Rabat A. | Centenary Stadium | ||
| 27/02/2011 | St. Patrick | 0 - 1 | Mellieha | Centenary Stadium | ||
| 28/02/2011 | Zejtun C. | 3 - 1 | Birzebbuga SP | Centenary Stadium | ||
| 28/02/2011 | Zebbug R. | 1 - 1 | Zurrieq | Centenary Stadium | ||
| Round 17 | ||||||
| 06/03/2011 | Gzira U. | 1 - 3 | St. Patrick | Centenary Stadium | ||
| 06/03/2011 | Birzebbuga SP | 2 - 1 | Mgarr U. | Centenary Stadium | ||
| 06/03/2011 | Rabat A. | 0 - 1 | San Gwann | Centenary Stadium | ||
| 06/03/2011 | Naxxar L. | 4 - 0 | Senglea A. | Centenary Stadium | ||
| 12/03/2011 | Mellieha | 0 - 3 | Zebbug R. | Centenary Stadium | ||
| 12/03/2011 | Zurrieq | 1 - 4 | Zejtun C. | Centenary Stadium | ||
| Round 18 | ||||||
| 13/03/2011 | Rabat A. | 2 - 0 | Naxxar L. | Centenary Stadium | ||
| 13/03/2011 | St. Patrick | 1 - 0 | Senglea A. | Centenary Stadium | ||
| 19/03/2011 | San Gwann | 1 - 0 | Birzebbuga SP | Centenary Stadium | ||
| 19/03/2011 | Zebbug R. | 3 - 1 | Gzira U. | Centenary Stadium | ||
| 20/03/2011 | Mgarr U. | 1 - 3 | Zurrieq | Centenary Stadium | ||
| 20/03/2011 | Zejtun C. | 1 - 0 | Mellieha | Centenary Stadium | ||
| Round 19 | ||||||
| 31/03/2011 | Birzebbuga SP | 1 - 1 | Rabat A. | Centenary Stadium | ||
| 31/03/2011 | Naxxar L. | 2 - 2 | St. Patrick | Centenary Stadium | ||
| 02/04/2011 | Senglea A. | 0 - 2 | Zebbug R. | Centenary Stadium | ||
| 02/04/2011 | Zurrieq | 4 - 2 | San Gwann | Centenary Stadium | ||
| 03/04/2011 | Gzira U. | 2 - 3 | Zejtun C. | Centenary Stadium | ||
| 03/04/2011 | Mellieha | 6 - 0 | Mgarr U. | Centenary Stadium | ||
| Round 20 | ||||||
| 09/04/2011 | Birzebbuga SP | 1 - 5 | Naxxar L. | Centenary Stadium | ||
| 09/04/2011 | Zebbug R. | 0 - 1 | St. Patrick | Centenary Stadium | ||
| 10/04/2011 | Rabat A. | 2 - 0 | Zurrieq | Centenary Stadium | ||
| 10/04/2011 | Zejtun C. | 0 - 0 | Senglea A. | Centenary Stadium | ||
| 11/04/2011 | San Gwann | 2 - 1 | Mellieha | Centenary Stadium | ||
| 11/04/2011 | Mgarr U. | 2 - 0 | Gzira U. | Centenary Stadium | ||
| Round 21 | ||||||
| 16/04/2011 | Zurrieq | 0 - 1 | Birzebbuga SP | Centenary Stadium | ||
| 16/04/2011 | Naxxar L. | 3 - 2 | Zebbug R. | Centenary Stadium | ||
| 17/04/2011 | St. Patrick | 0 - 4 | Zejtun C. | Centenary Stadium | ||
| 17/04/2011 | Mellieha | 0 - 0 | Rabat A. | Centenary Stadium | ||
| 18/04/2011 | Senglea A. | 0 - 1 | Mgarr U. | Centenary Stadium | ||
| 18/04/2011 | Gzira U. | 2 - 5 | San Gwann | Centenary Stadium | ||
| Round 22 | ||||||
| 30/04/2011 | Zurrieq | 0 - 0 | Naxxar L. | Centenary Stadium | ||
| 30/04/2011 | Zejtun C. | 6 - 1 | Zebbug R. | Centenary Stadium | ||
| 01/05/2011 | Birzebbuga SP | 1 - 0 | Mellieha | Centenary Stadium | ||
| 01/05/2011 | Mgarr U. | 0 - 4 | St. Patrick | Centenary Stadium | ||
| 02/05/2011 | Rabat A. | 7 - 2 | Gzira U. | Centenary Stadium | ||
| 02/05/2011 | San Gwann | 6 - 3 | Senglea A. | Centenary Stadium |