| Matches by round |
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
| Match list: | By round By date Latest | Player stats: |
| R | Date | Home | Score | Away | Location | |
| 1 | 02/10/2010 | San Gwann | 1 - 2 | St. Patrick | Centenary Stadium | |
| 2 | 10/10/2010 | St. Patrick | 0 - 4 | Rabat A. | Centenary Stadium | |
| 3 | 17/10/2010 | Birzebbuga SP | 1 - 0 | St. Patrick | Centenary Stadium | |
| 4 | 30/10/2010 | St. Patrick | 2 - 0 | Zurrieq | Centenary Stadium | |
| 5 | 06/11/2010 | Mellieha | 3 - 1 | St. Patrick | Centenary Stadium | |
| 6 | 14/11/2010 | St. Patrick | 1 - 1 | Gzira U. | Centenary Stadium | |
| 7 | 21/11/2010 | Senglea A. | 7 - 1 | St. Patrick | Centenary Stadium | |
| 8 | 12/12/2010 | St. Patrick | 3 - 0 | Naxxar L. | Centenary Stadium | |
| 9 | 18/12/2010 | St. Patrick | 3 - 0 | Zebbug R. | Centenary Stadium | |
| 10 | 03/01/2011 | Zejtun C. | 4 - 0 | St. Patrick | Centenary Stadium | |
| 11 | 15/01/2011 | St. Patrick | 2 - 0 | Mgarr U. | Centenary Stadium | |
| 12 | 24/01/2011 | St. Patrick | 3 - 1 | San Gwann | Centenary Stadium | |
| 13 | 31/01/2011 | Rabat A. | 0 - 0 | St. Patrick | Centenary Stadium | |
| 14 | 10/02/2011 | St. Patrick | 2 - 0 | Birzebbuga SP | Centenary Stadium | |
| 15 | 20/02/2011 | Zurrieq | 2 - 0 | St. Patrick | Centenary Stadium | |
| 16 | 27/02/2011 | St. Patrick | 0 - 1 | Mellieha | Centenary Stadium | |
| 17 | 06/03/2011 | Gzira U. | 1 - 3 | St. Patrick | Centenary Stadium | |
| 18 | 13/03/2011 | St. Patrick | 1 - 0 | Senglea A. | Centenary Stadium | |
| 19 | 31/03/2011 | Naxxar L. | 2 - 2 | St. Patrick | Centenary Stadium | |
| 20 | 09/04/2011 | Zebbug R. | 0 - 1 | St. Patrick | Centenary Stadium | |
| 21 | 17/04/2011 | St. Patrick | 0 - 4 | Zejtun C. | Centenary Stadium | |
| 22 | 01/05/2011 | Mgarr U. | 0 - 4 | St. Patrick | Centenary Stadium |