| R | Date | Home | Score | Away | Location | |
| 1 | 24/09/2005 | Mellieha | 1 - 1 | Vittoriosa S. | Centenary Stadium | |
| 2 | 02/10/2005 | Balzan Y. | 2 - 0 | Mellieha | Centenary Stadium | |
| 3 | 09/10/2005 | Mellieha | 0 - 0 | Qormi | Centenary Stadium | |
| 4 | 16/10/2005 | Gudja U. | 0 - 3 | Mellieha | Centenary Stadium | |
| 5 | 23/10/2005 | Mellieha | 3 - 0 | Attard | Centenary Stadium | |
| 6 | 07/11/2005 | Mellieha | 3 - 1 | Gozo | Centenary Stadium | |
| 7 | 18/11/2005 | Mellieha | 4 - 3 | Gharghur | Centenary Stadium | |
| 8 | 26/11/2005 | Melita | 2 - 0 | Mellieha | Centenary Stadium | |
| 9 | 04/12/2005 | Mellieha | 1 - 1 | Dingli S. | Centenary Stadium | |
| 10 | 07/01/2006 | Zebbug R. | 1 - 1 | Mellieha | Centenary Stadium | |
| 11 | 14/01/2006 | Mellieha | 1 - 1 | Gzira U. | Centenary Stadium | |
| 12 | 21/01/2006 | Vittoriosa S. | 1 - 2 | Mellieha | Centenary Stadium | |
| 13 | 04/02/2006 | Mellieha | 3 - 1 | Balzan Y. | Centenary Stadium | |
| 14 | 10/02/2006 | Qormi | 1 - 3 | Mellieha | Centenary Stadium | |
| 15 | 19/02/2006 | Mellieha | 2 - 0 | Gudja U. | Centenary Stadium | |
| 16 | 04/03/2006 | Attard | 2 - 2 | Mellieha | Centenary Stadium | |
| 17 | 12/03/2006 | Gozo | 2 - 1 | Mellieha | Gozo Stadium | |
| 18 | 25/03/2006 | Gharghur | 0 - 6 | Mellieha | Centenary Stadium | |
| 19 | 02/04/2006 | Mellieha | 3 - 1 | Melita | Centenary Stadium | |
| 20 | 10/04/2006 | Dingli S. | 0 - 0 | Mellieha | Centenary Stadium | |
| 21 | 29/04/2006 | Mellieha | 0 - 1 | Zebbug R. | Centenary Stadium | |
| 22 | 06/05/2006 | Gzira U. | 1 - 0 | Mellieha | Centenary Stadium |
| Created on 09/05/2006 with LeaguePad |
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| Dingli S. Matches |
| Gharghur Matches |
| Gozo Matches |
| Gudja U. Matches |
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| Zebbug R. Matches |