| R | Date | Home | Score | Away | Location | |
| 1 | 02/10/2005 | Sirens | 2 - 0 | Kalkara | Centenary Stadium | |
| 2 | 16/10/2005 | Zejtun C. | 1 - 4 | Sirens | Centenary Stadium | |
| 3 | 28/10/2005 | Sirens | 2 - 1 | Luqa SA | Centenary Stadium | |
| 4 | 14/11/2005 | Zurrieq | 1 - 1 | Sirens | Centenary Stadium | |
| 5 | 27/11/2005 | Sirens | 0 - 2 | Sta. Venera L. | Centenary Stadium | |
| 6 | 08/12/2005 | Pembroke A. | 0 - 1 | Sirens | Centenary Stadium | |
| 7 | 13/12/2005 | Sirens | 2 - 3 | Sta. Lucia | Centenary Stadium | |
| 8 | 15/01/2006 | Mgarr U. | 0 - 2 | Sirens | Centenary Stadium | |
| 9 | 29/01/2006 | Sirens | 0 - 1 | Rabat A. | Centenary Stadium | |
| 10 | 11/02/2006 | Ghaxaq | 0 - 1 | Sirens | Centenary Stadium | |
| 11 | 24/02/2006 | Sirens | 0 - 2 | Birzebbuga SP | Centenary Stadium | |
| 12 | 10/03/2006 | Xghajra T. | 2 - 2 | Sirens | Centenary Stadium | |
| 13 | 24/03/2006 | Sirens | 2 - 0 | Ta Xbiex | Centenary Stadium | |
| 14 | 01/04/2006 | Siggiewi | 1 - 2 | Sirens | Centenary Stadium | |
| 15 | 17/04/2006 | Sirens | 1 - 0 | Kirkop U. | Centenary Stadium | |
| 16 | 28/04/2006 | Fgura U. | 0 - 3 | Sirens | Centenary Stadium |
| Created on 07/05/2006 with LeaguePad |
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