| R | Date | Home | Score | Away | Location | |
| 1 | 11/09/2005 | St. Andrews | 0 - 1 | Senglea A. | V. Tedesco Stadium | |
| 2 | 18/09/2005 | St. Georges | 1 - 0 | St. Andrews | V. Tedesco Stadium | |
| 3 | 01/10/2005 | St. Andrews | 1 - 1 | St. Patrick | V. Tedesco Stadium | |
| 4 | 14/10/2005 | Mqabba | 2 - 0 | St. Andrews | Centenary Stadium | |
| 5 | 29/10/2005 | St. Andrews | 2 - 2 | Tarxien R. | Centenary Stadium | |
| 6 | 19/11/2005 | Marsa | 1 - 1 | St. Andrews | Centenary Stadium | |
| 7 | 30/11/2005 | St. Andrews | 3 - 2 | Lija A. | Centenary Stadium | |
| 8 | 16/12/2005 | San Gwann | 3 - 0 | St. Andrews | Centenary Stadium | |
| 9 | 18/01/2006 | Naxxar L. | 3 - 0 | St. Andrews | Centenary Stadium | |
| 10 | 05/02/2006 | Senglea A. | 3 - 1 | St. Andrews | V. Tedesco Stadium | |
| 11 | 05/03/2006 | St. Andrews | 0 - 3 | St. Georges | V. Tedesco Stadium | |
| 12 | 25/03/2006 | St. Patrick | 5 - 1 | St. Andrews | Hibs Ground | |
| 13 | 02/04/2006 | St. Andrews | 0 - 1 | Mqabba | V. Tedesco Stadium | |
| 14 | 09/04/2006 | Tarxien R. | 1 - 1 | St. Andrews | V. Tedesco Stadium | |
| 15 | 16/04/2006 | St. Andrews | 1 - 1 | Marsa | V. Tedesco Stadium | |
| 16 | 23/04/2006 | Lija A. | 4 - 2 | St. Andrews | V. Tedesco Stadium | |
| 17 | 30/04/2006 | St. Andrews | 0 - 2 | San Gwann | V. Tedesco Stadium | |
| 18 | 07/05/2006 | St. Andrews | 0 - 4 | Naxxar L. | V. Tedesco Stadium |
| Created on 14/05/2006 with LeaguePad |
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| League tables |
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| Team pages |
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| Naxxar L. Matches |
| San Gwann Matches |
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| St. Patrick Matches |
| Tarxien R. Matches |