| R | Date | Home | Score | Away | Location | |
| 1 | 26/09/2005 | Attard | 1 - 1 | Melita | Centenary Stadium | |
| 2 | 03/10/2005 | Melita | 1 - 2 | Gharghur | Centenary Stadium | |
| 3 | 15/10/2005 | Dingli S. | 0 - 0 | Melita | Centenary Stadium | |
| 4 | 22/10/2005 | Melita | 3 - 2 | Gzira U. | Centenary Stadium | |
| 5 | 31/10/2005 | Balzan Y. | 0 - 2 | Melita | Centenary Stadium | |
| 6 | 11/11/2005 | Melita | 0 - 2 | Gudja U. | Centenary Stadium | |
| 7 | 21/11/2005 | Melita | 4 - 0 | Gozo | Centenary Stadium | |
| 8 | 26/11/2005 | Melita | 2 - 0 | Mellieha | Centenary Stadium | |
| 9 | 08/12/2005 | Melita | 1 - 2 | Zebbug R. | Centenary Stadium | |
| 10 | 07/01/2006 | Vittoriosa S. | 4 - 2 | Melita | Centenary Stadium | |
| 11 | 15/01/2006 | Melita | 0 - 1 | Qormi | Centenary Stadium | |
| 12 | 28/01/2006 | Melita | 1 - 2 | Attard | Centenary Stadium | |
| 13 | 05/02/2006 | Gharghur | 0 - 0 | Melita | Centenary Stadium | |
| 14 | 18/02/2006 | Melita | 0 - 0 | Dingli S. | Centenary Stadium | |
| 15 | 26/02/2006 | Gzira U. | 1 - 6 | Melita | Centenary Stadium | |
| 16 | 11/03/2006 | Melita | 3 - 1 | Balzan Y. | Centenary Stadium | |
| 17 | 18/03/2006 | Gudja U. | 2 - 2 | Melita | Centenary Stadium | |
| 18 | 26/03/2006 | Gozo | 2 - 1 | Melita | Gozo Stadium | |
| 19 | 02/04/2006 | Mellieha | 3 - 1 | Melita | Centenary Stadium | |
| 20 | 22/04/2006 | Zebbug R. | 0 - 2 | Melita | Centenary Stadium | |
| 21 | 30/04/2006 | Melita | 0 - 2 | Vittoriosa S. | Centenary Stadium | |
| 22 | 07/05/2006 | Qormi | 2 - 0 | Melita | Centenary Stadium |
| Created on 09/05/2006 with LeaguePad |
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| Team pages |
| Attard Matches |
| Balzan Y. Matches |
| Dingli S. Matches |
| Gharghur Matches |
| Gozo Matches |
| Gudja U. Matches |
| Gzira U. Matches |
| Melita Matches |
| Mellieha Matches |
| Qormi Matches |
| Vittoriosa S. Matches |
| Zebbug R. Matches |