| R | Date | Home | Score | Away | Location | |
| 16 | 21/01/2006 | Hamrun S. | 0 - 6 | Birkirkara | National Stadium | |
| 16 | 24/01/2006 | Mosta | 0 - 3 | Floriana | Centenary Stadium | |
| 16 | 24/01/2006 | Sliema W. | 0 - 0 | Marsaxlokk | Centenary Stadium | |
| 16 | 28/01/2006 | Hibernians | 1 - 2 | Valletta | National Stadium | |
| 16 | 29/01/2006 | Pietà H. | 0 - 0 | Msida SJ | V. Tedesco Stadium |
| Created on 14/05/2006 with LeaguePad |
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| Hibernians Matches |
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| Pietà H. Matches |
| Sliema W. Matches |
| Valletta Matches |