| R | Date | Home | Score | Away | Location | |
| 1 | 11/08/2005 | Hamrun S. | 1 - 2 | Marsaxlokk | National Stadium | |
| 3 | 22/08/2005 | Birkirkara | 1 - 1 | Marsaxlokk | National Stadium | |
| 2 | 25/08/2005 | Marsaxlokk | 5 - 1 | Mosta | National Stadium | |
| 4 | 11/09/2005 | Marsaxlokk | 2 - 3 | Valletta | National Stadium | |
| 5 | 18/09/2005 | Msida SJ | 1 - 1 | Marsaxlokk | National Stadium | |
| 6 | 21/09/2005 | Marsaxlokk | 1 - 1 | Floriana | National Stadium | |
| 7 | 01/10/2005 | Marsaxlokk | 1 - 2 | Sliema W. | National Stadium | |
| 8 | 16/10/2005 | Pietà H. | 1 - 4 | Marsaxlokk | National Stadium | |
| 9 | 23/10/2005 | Marsaxlokk | 1 - 4 | Hibernians | National Stadium | |
| 10 | 30/10/2005 | Marsaxlokk | 4 - 3 | Hamrun S. | National Stadium | |
| 11 | 20/11/2005 | Mosta | 1 - 3 | Marsaxlokk | V. Tedesco Stadium | |
| 12 | 08/12/2005 | Marsaxlokk | 2 - 0 | Birkirkara | National Stadium | |
| 13 | 03/01/2006 | Valletta | 0 - 4 | Marsaxlokk | National Stadium | |
| 14 | 08/01/2006 | Marsaxlokk | 1 - 0 | Msida SJ | Hibernians Ground | |
| 15 | 17/01/2006 | Floriana | 1 - 2 | Marsaxlokk | Centenary Stadium | |
| 16 | 24/01/2006 | Sliema W. | 0 - 0 | Marsaxlokk | Centenary Stadium | |
| 17 | 04/02/2006 | Marsaxlokk | 1 - 3 | Pietà H. | Hibernians Ground | |
| 18 | 11/02/2006 | Hibernians | 0 - 1 | Marsaxlokk | National Stadium | |
| 19 | 05/03/2006 | Marsaxlokk | 2 - 1 | Sliema W. | Hibernians Ground | |
| 20 | 12/03/2006 | Marsaxlokk | 1 - 0 | Msida SJ | Hibernians Ground | |
| 21 | 18/03/2006 | Birkirkara | 1 - 0 | Marsaxlokk | National Stadium | |
| 22 | 26/03/2006 | Marsaxlokk | 3 - 4 | Valletta | National Stadium | |
| 23 | 01/04/2006 | Hibernians | 3 - 1 | Marsaxlokk | National Stadium | |
| 24 | 16/04/2006 | Sliema W. | 0 - 1 | Marsaxlokk | National Stadium | |
| 25 | 22/04/2006 | Msida SJ | 3 - 4 | Marsaxlokk | National Stadium | |
| 26 | 30/04/2006 | Marsaxlokk | 1 - 1 | Birkirkara | National Stadium | |
| 27 | 05/05/2006 | Valletta | 0 - 2 | Marsaxlokk | National Stadium | |
| 28 | 13/05/2006 | Marsaxlokk | 1 - 0 | Hibernians | National Stadium |
| Created on 14/05/2006 with LeaguePad |
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| Hibernians Matches |
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| Pietà H. Matches |
| Sliema W. Matches |
| Valletta Matches |